The Future of Aging: Pathways to Human Life Extension

Editor: Gregory M. Fahy
Technical Editors: Michael D. West, L. Stephen Coles, Steven B. Harris

To my mind this is a must-read book for anybody who cares about themselves and their future. An outstanding panel of authors brings their expertise to the audience in 23 chapters of what I’m sure is terrific reading. Take a look at the table of contents below and you’ll understand what I’m talking about.


Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological “bailout” could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context.

Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete. Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology. The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.


Part 1: Introduction and Orientation

Chapter 1 Bridges to LifeRay Kurzweil, Kurzweil Technologies, Inc. Wellesley, MA, and Terry Grossman, M.D., Frontier Medical Institute, Denver, CO;

Chapter 2 Analyzing Predictions: An Anthropological View of Anti-Aging FuturesCourtney Everts Mykytyn, Ph.D., Department of Anthropology, University of Southern California, Los Angeles, CA, USA;

Chapter 3 Towards Naturalistic Transcendence: The Value of Life and Life Extension to Persons as Conative Processes – Steven Horrobin, Ph.D., College of Medicine, University of Edinburgh, Scotland, UK;

Chapter 4 The Ethical Basis for Using Human Embryonic Stem Cells in the Treatment of AgingL. Stephen Coles, M.D., Ph.D., David Geffen School of Medicine, UCLA, Los Angeles, CA, USA;

Chapter 5 Evolutionary Origins of AgingJoshua Mitteldorf, Ph.D., Dept of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ

Chapter 6 Precedents for the Biological Control of Aging: Experimental Postponement, Prevention, and Reversal of Aging ProcessesGregory M. Fahy, Ph.D., Intervene Biomedical, Norco, CA, USA;

Part 2: The Future of Aging

Chapter 7 An Approach to Extending Healthspan and Lifespan TodayChris Heward, Ph.D.*, President, Kronos Science Laboratory, Phoenix, AZ, USA; *Deceased

Chapter 8 Near-Term Prospects for Amelioration of Cardiovascular AgingRoger Yu, M.D., Beth Israel Deaconess Medical Center, Boston, MA 02215, and Mohammad Navab, Ph.D., David Geffen School of Medicine, UCLA, Los Angeles, CA, USA;

Chapter 9 Near Term Prospects for Broad Spectrum Amelioration of CancerZheng Cui, Ph.D., Wake Forest University School of Medicine, inston-Salem, NC, USA;

Chapter 10 Small Molecule Modulators of Sirtuin Activity – Francisco J. Alcain, Ph.D., Robin K. Minor, Ph.D., Jose M. Villalba, Ph.D., Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain, and Rafael de Cabo, Ph.D., Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA;

Chapter 11 Evolutionary NutrigenomicsMichael Rose, Ph.D., Anthony D. Long, Ph.D., Laurence D. Mueller, Ph.D., Cristina L. Rizza, Ph.D., Kennedy C. Matsagas, Ph.D., Lee F. Greer, Ph.D., and Bryant Villeponteau, Ph.D.Genescient, LLC, Irvine, CA, USA;

Chapter 12 Biological Effects of Calorie Restriction:Implications for Modification of Human AgingStephen R. Spindler, Ph.D., Department of Biochemistry,University of California at Riverside, Riverside, CA, USA;

Chapter 13 Calibrating Notch/TGF-ß Signaling for Youthful, Healthy Tissue Maintenance and Repair – Morgan E. Carlson, Ph.D. and Irina M. Conboy, Ph.D., Department of Bioengineering, University of California, Berkeley, CA, USA;

Chapter 14 Embryonic Stem Cells:Prospects of Regenerative Medicinefor the Treatment of Human AgingMike West, Ph.D., Chief Scientific Officer, BioTime, Inc., and Embryome Sciences, Inc., Alameda, CA, USA, and Adjunct Professor, University of California at Berkeley, Berkeley, CA, USA

Chapter 15 Maintenance and Restoration of Immune System FunctionRichard Aspinall, Ph.D., and Wayne Mitchell, Ph.D., School of Medicine, Division of Investigative Science,Imperial College London, London, UK

Chapter 16 Mitochondrial Manipulation as a Treatment for AgingRafal Smigrodzki, M.D., and Francisco R. Portell, B.S., Gencia, Inc., Charlottesville, VA, USA;

Chapter 17 Life Extension by Tissue and Organ ReplacementAnthony Atala, M.D., Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA;

Chapter 18 Telomeres and the Arithmetic of Human LongevityAbraham Aviv, M.D., and John D. Bogden, Ph.D., The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ

Chapter 19 Repairing Extracellular Aging and GlycationJohn Furber, C.E.O., Legendary Pharmaceuticals, Inc., Gainesville, FL USA;

Chapter 20 Methuselah’s DNA: Defining Genes that Can Extend LongevityRobert J. Shmookler-Reis, Ph.D., and Joan McEwen, Ph.D. , VA Medical Center, University of Arkansas for Medical Science, Little Rock, AR, USA

Chapter 21 Reversing Age-Related DNA Damage through Engineered DNA RepairClifford Steer, M.D., Director, Molecular Gastroenterology Program, and Betsy Kren, Ph.D., Department of Medicine, GI Division, University of Minnesota Medical School, Minneapolis, MN, USA

Chapter 22 WILT: Necessity, Feasibility, AffordabilityAubrey de Grey, Ph.D., Methuselah Foundation, Lorton, VA, USA;

Chapter 23 Comprehensive Nanorobotic Control of Human Morbidity and AgingRobert A. Freitas, Jr., J.D., Institute for Molecular Manufacturing, Palo Alto, CA, USA;

The book will be released on October, 2, but you can pre-order it on Amazon.


Filed under Life Extension, Transhumanism

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