Freezing without cryoprotectants

A solution for the cryopreservation of human internal organs could be at hand in the form of a technology used to preserve sushi that can instantly freeze water, meaning there is no time for cell damaging ice crystals to form. In fact, it’s already being used to preserve teeth.

A research group at Hiroshima University, borrowing super-cooling technology used to preserve sushi and high-end food delicacies, has proven it is possible to freeze cells without the use of toxic cryprotectants. As reported on Singularity Hub, the “Cells Alive System” (CAS) produced by Japanese company ABI prevents freezing at super-cool temperatures by vibrating the water using magnetic fields. This allows the water to be super-cooled so that when the magnetic field is turned off, the water freezes instantaneously – too fast for damaging ice crystals to form.

The patented CAS technology is already being used at the world’s first commercial tooth bank, The Teeth Bank, to preserve teeth and potentially as an alternative source for harvesting stem cells. The Teeth Bank allows removed teeth, previously disposed of as worthless medical waste, to be stored and re-implanted when needed. Preserved teeth can even be sculpted into different teeth before re-implantation.

The CAS technology has even been proven to reserve the tooth ligaments – an important factor for re-implantation. A 2010 study published in the journal Cryobiology detailed how the ligaments of a fresh tooth slow frozen without the CAS technology were severely damaged, while the ligaments of another tooth frozen using the CAS technology survived showing only minor damage and grew as well as those from a fresh tooth.

The technology could obviously have potential for the preservation of internal organs that currently have only a brief window of viability after being removed from a donor. Thanks to burgeoning technology, it could also provide a way for people to store replacement organs grown from their own stem cells instead of waiting on a compatible donor.

Read more about CAS technology



Filed under Cryonics

7 responses to “Freezing without cryoprotectants

  1. Rodney

    That’s half the problem; with this technology there would be no significant cellualr damaging with freezing. It looks like the thaw-out process would still induce damage and make cyropresvation of human organs not yet possible.

  2. Hmmm…interesting research. I’d urge caution on accepting the claimed benefits. From a recent post to the forums at

    Recently Japan Society of Refrigerating and Air Conditioning Engineers made a very serious research on efficacity of CAS. The title of thesis is “Experimental Investigation of Effectiveness of Magnetic Field on Food Freezing Process (Trans. od the JSRAE Vol.26, No.4 2009 pp371-386). The conclusion is “NO SIGNIFICANT DIFFERENCE”.

  3. Excellent post. Keep posting such kind of information on your
    blog. Im really impressed by your site.
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  4. If this research is duplicable and viable, then I think that cryopreservation companies like Alcor, would be deeply interested in it. As to the unfreezing exponent: why wouldn’t it be possible to reverse the process, using a magnetic vibration at the precise time the thawing process begins to break down the frozen object, then instituting a super thawing process that would unfreeze the object as quickly as it was frozen? I’m probably missing something, I’m sure, since I am not a microbiologist or biochemist. Just a layperson’s perspective.

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