NFkB Links Cancer and Aging


I found it quite interesting that mutations in multiple myeloma are located in the genes involved in NFkB pathway. This chain of events in the cell activates as a response to various kinds of stress, such as cytokines, free radicals, ultraviolet irradiation and other stressors. NFkB is a transcription factor which is responsible for activating genes linked to increased inflammation. Multiple myeloma genome sequencing revealed that this molecular pathway is altered. So apparently there’s a link between the aberrant activity of NFkB and cancer, and I would like to point out that there’s probably a link to aging as well. It is most likely that inhibition of this pathway may lead to cancer incidence reduction and also anti-aging effects. It has already been shown that pharmacological blocking of NFkB pathway prolongs lifespan in drosophila. Read the paper by Dr.Alexey Moskalev who’s done this experiment.

5 Comments

Filed under genomics

5 responses to “NFkB Links Cancer and Aging

  1. Maria:

    You might find this blog post interesting as well:
    http://math-blog.com/2011/10/07/tackling-cancer-with-math

  2. Excellent blog here! Also your web site quite a bit up very fast!
    What web host are you the usage of? Can I get your associate hyperlink
    for your host? I desire my website loaded up as quickly
    as yours lol

  3. Hello friends, good piece of writing and good arguments commented
    at this place, I am really enjoying by these.

  4. I’m really enjoying the design and layout of your
    website. It’s a very easy on the eyes which makes it much more pleasant for
    me to come here and visit more often. Did you hire
    out a developer to create your theme? Excellent work!

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s