Category Archives: Policy

Neverending Sex

2015-07-27 23.05.31Let’s formulate the task of life extension slightly differently. Something like this…How can we extend sex appeal?

Gyms and beauty salons are in charge of this question now. There is some success, but it’s mostly superficial. Plastic surgery only masks, but doesn’t delay the processes of aging.

Expanding sex appeal is a complex task. Its aspects include both beauty and the activity of the brain. To be sexually attractive we have to be smart and fun. One cannot solve the problem of dementia with makeup. 

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It is Unethical Not to Use Genetic Engineering

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When I hear that the conversation is about an ethical problem I anticipate that right now the people are going to put everything upside down and end with common sense. Appealing to ethics has always been the weapon of conservatism, the last resort of imbecility.

How does it work? At the beginning you have some ideas, but in the end it’s always a “no”. The person speaking on the behalf of ethics or bioethics is always against the progress, because he or she is basing their opinion on their own conjectures. What if the GMO foods will crawl out of the garden beds and eat us all? What if there will be inequality when some will use genetic engineering for their kids and some won’t? Let’s then close down the schools and universities – the main source of inequality. What if some will get the education and other won’t?

That’s exactly the position that ‪Elon Musk took by fearing the advances in genetic engineering. Well, first of all, there already is plenty of inequality. It is mediated by social system, limited resources and genetic diversity. First of all, why should we strive for total equality? More precisely, why does the plank of equality have to be based on a low intellectual level? How bad is a world where the majority of people are scientists? How bad is a world where people live thousands of years and explore deep space? It’s actually genetic engineering that gives us these chances. From the ‪#‎ethics‬ point of view things are visa versa. It’s refusing the very possibility of helping people is a terrible deed. Let’s not improve a person, because if we do what if this person becomes better than everybody else? Let’s not treat this person, because if we do he might live longer than everybody else? Isn’t this complete nonsense?

There’s another aspect of ‪#‎geneticengineering‬ – people always talk about improving the children, however genetic engineering first and foremost gives the opportunity to improve the already living people. Gene therapies already exist and it would be wonderful if we could live to see the moment when they are able to improve our health and intellect many fold. It is obvious that these technologies have to be safe. So, if we can help a child or a grown up, let’s do it immediately. This is the real ethic position.

I will also allow myself to speculate that genetic engineering is the fastest track towards Artificial Intelligence. The majority thinks that AI will arise in a computer, but I think it might be easier to grow the superbrain and train it. And yes, with the help of genetic engineering.

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Civil Activism

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What Should Be Done to Achieve Radical Life Extension?

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Theoretically the problem is already solved. It is now quite obvious what kind of research should be done for life extension. For example, testing various combinations of different things that extend lifespan in old mice. Particularly important is longevity gene therapy development.

Delivering 5-7 gene vectors simultaneously carrying longevity-associated genes into an old animal could prove to be quite beneficial, because similar approach already works.

It is also clear that there are several experiments in the area of therapeutic cloning that should be done immediately.

There are about 20 other research directions in the area of radical life extension. I’d like to just also mention implementing aging diagnostics into clinical practice.

There are approximately 50 labs in the states that move into the right direction. They could do much more if they had more money.

Well, it’s all about the money, but not really big money.

Transhumanists from all over the world have been trying to solve the mystery of how to secure funding for reaching physical immortality. The very development of science leads towards it, but this process is too slow, a lot of people may not make it in time. Our goal is to accelerate.

Right now it has become obvious how to find the money for radical life extension. It’s crowdfunding. 200-300 campaigns need to be created on various crowdfunding platforms on the topics of fighting aging and regenerative medicine.

Of course, we may not be able to find the necessary amounts of money right away, but we will be able to delineate the scope of goals, most importantly not using just the general words, but particular scientists, labs and research plans.

Even by only preparing the campaigns we will influence the society by once again providing the proof of the possibility of significant life extension. Unfortunately, molecular biology is not part of an every day’s person background. We will make people more educated, show them how diseases originate, progress, and how they relate to aging. We will also tell the people what can be done.

While working on the crowdfunding campaigns we will mobilize our supporters by giving them a concrete tool and a plan of action. Fighting aging crowdfunding will become a very powerful transhumanist organizational solution.

In the end we will gather the money, implement our projects and win!

If you are interested in bringing this plan to live, let’s collaborate. Every single project requires a manager, analyst, scientist, director, operator, a guy who owns a car and a guy who writes a lot about this on the Internet. There is work for everybody, so let’s do this.

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A Question to the Lawyers

The Declaration of Independence, adopted by the US Congress on July 4, 1776, says:

“We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the pursuit of Happiness.

That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed, That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness.”

Aging makes people unhappy and bereaves them of their lives. Meaning all the citizens of the US lose their unalienable rights. Provided that the Government is not trying to defeat aging, is it acting in the interest of the People?

Is the Declaration of Independence a document of direct force? Are there any legal grounds to demand that the Congress funds curing aging?

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Life Extension is a Political Task

Sooner or later the human life extension problem, the task of achieving immortality will become the main issue of government policies in developed countries of the world. This will happen on its own because of the exponential growth of technologies.

At some point of time immortality will become the main political question.

This is inevitable. 

Nevertheless, let’s make this process faster to save millions of lives. In order to make this leap towards human radical life extension, political will is needed.

Without it there is no money for new research, no laws permitting the most radical experiments (cloning and transplanting a mammal’s head), there is no fast approval of new therapeutics. There is no proper interest.

We consider the gay community fighting for anti-AIDS drugs development against FDA an excellent example of political struggle. It is pictured in the How to survive the plague movie and its trailer.

Here we see the main signs of successful political struggle – large amounts of people uniting, heating of emotions, street actions, using speech, music, slogans and any other features. Vigor in being ready to fight for the right to live.

This is a spectacular example to follow. A call for action to fight for lifespan increase.

The majority of transhumanist efforts were dedicated to trying to persuade the billionaires. At large, this strategy failed. Billionaires are billionaires because they love money more than their own lives.

The major result here is Google creating Calico company. Calico’s budget was announced to be several hundreds of million dollars. However, it is still unclear what Calico will be doing. The research plan wasn’t shared with the public.

There are several reasons why persuading the billionaires failed – their preoccupation with immediate return, their religious beliefs (Steve Jobs), their irrationality and so on.

Therefore, there are only two possible addressees of our message – the government and the people. In a democratic state the policy is defined by the people’s choice, and because of this crowd activity is particularly necessary to influence the state. Moreover, the people can substitute the state. For example, back in the day the government gathered taxes from the people and spent them on various projects, but now the people can do the very same thing using crowdfunding and substitute the government. Although, perhaps, in the future we will see transhumanist parties in parliaments.

Various public actions can influence government policy. It is our task to prepare actions in favor of life extension. An idea acquired by the masses is material, Lenin wrote.

If a given idea has 20 million followers, it doesn’t need a state to win. It has already won. It can form an alternative system of decision making on the Internet, i.e. create the crowd-power.

Radical life extension is the strongest idea in the history of mankind. The Pirate party and the Green party may serve as an example of how the international life extension party will be created. First of all, there has to be a circle of people who share the same value, and separate flamboyant actions that highlight this value. Just like Greenpeace performed this action when they sailed to the island where the nuclear testing was about to take place.

However we are aware that radical life extension idea still hasn’t got enough followers, and public actions are needed to attract new supporters, because actionism is also quite fascinating. Maybe we should float 400 coffins into the Hudson River so that people will see with their own eyes how many people die in New York every day.

Another way of using the power of the crowd is crowdfunding of scientific experiments.

And it’s important to say that there are such experiments that possess the power of political acts, meaning they extend the limits of what’s possible and set the direction of further movement.

It so happens when the first step in some activity sets the direction, for example when a person gets admitted to university for particular major, this defines his movement on the professional ladder – whether he will become an economist or a dentist, a marine or an AI developer. Yes, options are possible, but the first actions triggers the following ones.

We have to find exactly this kind of solutions in our field.

For example, transplanting a head from one mammal to another will become the discovery of the whole area of research, but right now this procedure is not permitted because of the pseudoethical beliefs in the majority of the countries in the world. Today the most obscurant people with cave world view bloviate about bioethics.

What kind of experiments are those?

Restoring the activity in brain samples

One of the main arguments against cryonics is that it’s unclear whether the memory of the person will survive the freezing. However, it is well known that nematode worms survive the freezing in liquid nitrogen quite well, meaning separate neurons can survive the freezing. The question is if we teach the worm do something and cryopreserve it, will the acquired memory be intact after we warm it up? If so, then we will be able to do this experiment in more complicated organisms. If not, then… we still should move to more complicated models and study the requirements for memory preserving.

Implementing aging diagnostics in the clinical setting

If we are able to do aging diagnostics, we will be able to measure the efficacy of anti-aging drugs much faster than watching whole generations of humans age, meaning we will see the effects within our lifetime. This is how aging will stop being a black box and will become a quantitative and changeable parameter.

Testing various substances and therapies on longevity will stop being some shaman magic and will gain solid scientific basis. Drug development will become very rapid and significant human life extension will be achieved.

Life extension in old mice using longevity associated genes

We can use genetic vectors and other technologies to insert various genes associated with longevity in adult mice, and we can select the combinations of those genes that will significantly increase lifespan. This will pave the way to creating human longevity genetic engineering.

Let’s do those things to a rat that make the naked mole rat negligibly senescent.

Transplantation of therapeutically cloned organs

This experiment will illustrate the potential of therapeutic cloning and will open new opportunities in regenerative medicine.

Sustaining viability of a mammal’s head for more than 1 year outside the body

If we are able to sustain viability of a head outside the body, this will open up the new possibility for extending life in terminally ill people, including the transition to using the completely artificial body.

Working model of the nematode worm’s brain

It we are able to simulate the operations of the 300 neurons of the nematode and reconstruct its behavior, then we will prove the sufficiency of our knowledge for more complicated objects.

Applying AI for diagnostics using tens of thousands of parameters

AI can become a powerful player in healthcare – if we have the detailed information about our health, we will be able to easily prevent any kind of disorders on very early stages of their development. By doing so we will significantly reduce the risk of death. In the end AI will not only act as a physician, but it will also conduct scientific experiments and will guarantee human life, health and immortality.

Based on everything said I propose collaboration on the following three things:

First of all, crowdfunding of basic scientific research. There is a new service that would connect the public and medical research – LabCures. It will allow everyone to fund whichever research in life-sciences that they like.

Secondly, we propose to join the Longevity Party group on Facebook and use this resource for organizing street actions, demonstrations, graffiti and so on.

Thirdly, I invite everyone to come to our Genetics of Aging and Longevity conference in Sochi on April 6-10, 2014. The world’s leading aging researchers will gather there to discuss the latest research highlights in the field of life extension. We will be very happy to see volunteers on our conference.

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Longevity Party Manifesto

Longevity Party is an international union of people, who believe the main goal of each and everyone is development of scientific and technological progress, significant life extension and supporting unlimited enhancement of capabilities of a personality.

Longevity Party is the party of common sense.

Everyone has their own values in life – family, children, creativity, love, beauty, freedom, money, traveling, sex, power… But all these things can only make sense if the person is alive. The basic condition for existence and implementation of all values is life. Its significant extension by rational, scientifically proven methods is the wisest strategy for every one of us.

Longevity Party strives to fairness and happiness.

There is nothing more unfair than death. People don’t deserve death. Death, senility and diseases make a person unhappy. Fight for fairness and happiness for everyone is a fight against diseases, suffering, pain, aging and fighting for radical extension of human life.

Longevity Party advocates acceleration of human evolution.

Life is a form of organization of matter, focused in the first place on self-preservation. Life is an anti-entropy process. The essence of evolution is in development and a human being is the best example of it. It’s human nature to strive to enhance capabilities, expand and increase the scope of the personality. Humans are endowed with capacity to self-improvement. They can gain new knowledge and skills and use those to improve their organisms and the world around them. Human evolution has long been happening not only on the biological level, but also on scientific and technological and social levels. All people are interested in positive changes to happen as soon as possible.

Longevity Party is the party of progress.

The entire the history of humanity is the history of improved capabilities and increased life expectancy. Everything that makes our life better, longer, more comfortable and more replete is the result of progress. Nonetheless, there are dangers and risks associated with science and technology development. They reflect the forces of regress and entropy. These phenomena must be seen as unsolved problems of progress.

Longevity Party strives to preserve the civilization.

One of the problems of humanity is the global risks – events, as a result of which the civilization may be destroyed. It is necessary to evaluate these risks well in advance and prevent any possible negative scenario from happening. Longevity Party sets the goal of indestructibility of humanity.

Longevity Party proposes the absolute hierarchy of goals.

Given the conditions of limited financial and intellectual resources, it is crucial to identify the most important tasks and focus on solving them. Certainly, the most important task for the civilization is radical human life extension.

The following areas are most promising for developing scientific methods and technologies for radical life extension: regenerative medicine, personalized medicine, neuromodeling, aging diagnostics, gene therapy, creating artificial organs, improving methods of studying molecular biological processes, cryonics, mathematical modeling of biological processes, creating Artificial Intelligence, nanorobots, evolutionary biology of aging, development of futurology.

Longevity Party advocates proactive approach to life.

Given the current time limitations of human life, it is shortsighted to passively wait for technological achievements. It is crucial to do everything possible to extend your own lifespan – use methods of disease diagnostics and preventing, lead a healthy life style, improve your own scientific competence, actively support scientific research, aimed at reaching physical immortality, support cryonics as a means of restoring life-sustaining activities of the dead in the future.

Longevity Party sets the goal of rising to power in the majority of countries of the world in order to implement projects on significant human life extension.

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