Category Archives: Life Extension

Fours Stages of Curing Aging

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Curing aging has 4 stages: mild aging deceleration, dramatic aging deceleration, achieving negligible senescence and rejuvenation. Today we can definitively claim that the task of mild aging deceleration is theoretically solved.

We know the drugs and interventions that slow down aging in mammals. The only thing that we don’t know is dosages, regimes and drug combinations. Defining all of that is the goal of pre-clinical and clinical studies. They can be started immediately. It is also a good idea to do clinical studies of various diets aimed at improving human longevity.

Dramatic aging deceleration will be achieved using gene therapy. Breakthrough studies of lifespan extension in old model animals happened in this area quite recently. We know the genes and delivery methods, now we need a set of powerful experiments aimed at radical life extension. The subject of the intervention will not only be the human genome, but the genomes of the human microbiota.

Rearrangement of how the genome works, as well as genetically modified stem cell therapy and therapeutic cloning can provide negligible senescence.

However, rejuvenation of the organism is likely to be competing with the idea and the very possibility of changing the body as the personality substrate to something else. It is likely that our goal will be not the youth, but creating a more advanced organism capable of solving the task of its own indestructability.

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Longevity Cookbook Indiegogo Campaign Is the Most Effective Step You Can Take towards Your Longevity

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Something amazing has happened! We have launched our Longevity Cookbook Indiegogo Campaign.

Aging steals away your most valuable resource: time. The Longevity Cookbook is a strategy guide to help you get more time to experience the joy from everything that you like in life. Take yourself on a journey starting with nutrients and exercise regimes that goes on to exploring the usage of genetically modified symbiotic organisms and using gene therapy to boost your own longevity.

Contributing to ‪#LongevityCookbook‬ is the best way you can spend your money, because we are fighting for your life. Please, contribute and share the Longevity Cookbook campaign. Let’s defeat aging together!

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Discipline Is More Powerful than Motivation

maria konovalenko lab longevity aging research

I know a bunch of people who support life extension, but they are very busy. They are going to first of all deal with their stuff and only then become involved in anything related to longevity. It’s just that there is always stuff to do every day. Meanwhile, life is passing by. We may be simply late. Late by 10 years, by 1 year, by only 1 day. There can be no situation more stupid than being late to buy «my life» ticket. There is so few people in our field. To fight aging you don’t really need motivation, you need discipline. You have to just force yourself. Simply force yourself.

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Do Model Animals Tell Us Anything about Human Aging?

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I wrote a tiny report on the pluses and minuses of using model  animals in aging research.

Using model animals in gerontological studies has yielded an enormous wealth of useful information about the mechanisms of human aging and longevity. Animal models were crucial in identifying the conserved pathways that regulate human aging. Model organisms are fundamental for aging research, because there are serious limitations of using human subjects, such as the length of lifespan, genetic heterogeneity and vast differences in environmental influences. The shape of survival curves represents the health of the organism over time. Model organisms display significantly different lifespans, however the survival curves resemble those of humans quite remarkably. Despite this general similarity in the way we describe aging between humans and model animals, there are some distinct differences (Mitchell, Scheibye-Knudsen, Longo, & de Cabo, 2015). For instance, increasing Sir2 gene expression in yeast (Kaeberlein, McVey, & Guarente, 1999), nematodes (Tissenbaum & Guarente, 2001), and flies (Rogina & Helfand, 2004) boosts animal longevity. A small molecule called resveratrol was found to activate Sir2 and its mammalian ortholog SIRT1 (Howitz et al., 2003). Resveratrol extends lifespan of mice fed a high-fat diet (Baur et al., 2006), however it failed to have a beneficial longevity effect in mice on a standard diet (Pearson et al., 2008). This example highlights the fact that we cannot simply transfer the results of longevity interventions to humans and expect the same efficacy as in invertebrate models.

Everyday the researchers are broadening the understanding of human biology of aging with the help of various model systems. Each of them has its advantages and drawbacks. Let’s take a look at what those are for the most widely used animal models.

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Longevity Gene Therapy – Updated Projects

While discussing the longevity gene therapy project we encountered various questions and observations that prompted us to broaden the project and slightly change it. Generally, all the comments can be reduced into 5 main points:

  1. You need to enlarge the list of therapeutic genes by adding to it this and that.
  2. You want to use too many genes; therefore you need to make the project simpler by keeping only the most effective genes
  3. If you apply all the genes at the same time, some of them may cancel out the effects of other genes.
  4. Will it be safe to use viral vectors to deliver genetic constructs?
  5. How safe are therapeutic genes for the body?

Some of the observations were of completely opposite nature, so we decided to do 2 versions of the project. One of them is for aging geneticists. In it we almost double the list of the genes extending lifespan. This project will allow testing many poorly studied genes, but promising in terms of aging. Besides, some unexpected results can be obtained, which is always valuable.

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Popular Lectures on Gene Therapy

We have put together a list of popular science video lectures on gene therapy – one of the most promising molecular medicine directions. What makes this approach different is that nucleic acid molecules, DNA and RNA, are used as therapeutic agents.

To have the most general idea about the principles of gene therapy you can watch this video

The lecture by Dr. Hans-Peter Kiem from Fred Hutchinson Cancer Research Center at University of Washington provides more detailed information about the main approaches utilized by gene therapy, nucleic acid delivery methods into the cells and also the diseases that use gene therapy for treatment

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Let’s Bet on Money?

labcures1

Let’s make a bet? I will propose something incredibly effective in the area of life extension and no one will be able to suggest a better strategy. Deal?

First of all, let’s think about what KPI (Key Performance Indicators) can be applied to longevity? What will tell us that we are on the right way to immortality, but not moving in the opposite direction towards the grave.

The answer here lies on the surface.

The first thing is money. The more money is invested in projects on life extesnion, the better chances we have to stay alive.

The second thing is people. There’s a nuance here. How can we count the increase in number of people? I think we need to count the most devoted supporters in the first place. There are millions of people who don’t mind living longer. Many of them run in parks or read biotechnology news, but does their activity lead to radical life extension? In my opinion, no. Moreover, having found a simple recipe like a diet, yoga or Kurzweil’s promises that everything is going to happen on its own by 2030, this kind of longevity supporters don’t do anything, because subconsciously they have already found the solution to the problem.

I propose to take only those people into account, who are involved in projects on radical human life extension. How can we identify such a person? Oh, it’s very easy. He or she talks about it explicitly and their actions are adequate, meaning they are established socially.

The third KPI is the number of events. Conferences, books, round tables, articles, social actions, 40 people going to have a beer because of the approaching singularity, youtube videos, scientific projects, movies – all of that is needed in extra large quantities.

The forth thing is the effectiveness of collaboration. This one is complicated. Perhaps the number of people involved in the same transhumanist project needs to be taken in account.

So, what strategy will be most oriented towards increasing all of the 4 indices? What can yield more money, more people, more events and more collaboration?

It is crowdfunding of scientific projects in the area of longevity. First dozens and then hundreds of crowdfunding campaigns have to be created that would raize funding for longevity gene therapy, regenerative medicine, studying molecular mechanisms of aging and their relationship to pathologies.

Yes, perhaps, we will raize not a lot of moeny in the beginning, but the projects that describe the work of the scientists, they will stay and they will continuosly owrk towards educating, promoting and attracting supporters. Moreover, they will help the universities and research institutes get government grants and venture capital.

Joint donations for longevity research will draw people closer together and will allow to constantly increase the loyal audience. There will be a chain reaction – successful crowdfunding peojects will motivate to create more projects in our field.

A set of projects on life extension will give a clear signal to the society that great things can be done to secure the main human right – the eright to live.

This is the reason why I participated in creating LabCures, because I concider this project the best strategy for the initial kick off of novel research projects including longevity.

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