Tag Archives: age-related diseases

Longevity Cookbook Indiegogo Campaign Is the Most Effective Step You Can Take towards Your Longevity

longevity cookbook, health, rejuvenation, aging, cookbook, healthy eating

Something amazing has happened! We have launched our Longevity Cookbook Indiegogo Campaign.

Aging steals away your most valuable resource: time. The Longevity Cookbook is a strategy guide to help you get more time to experience the joy from everything that you like in life. Take yourself on a journey starting with nutrients and exercise regimes that goes on to exploring the usage of genetically modified symbiotic organisms and using gene therapy to boost your own longevity.

Contributing to ‪#LongevityCookbook‬ is the best way you can spend your money, because we are fighting for your life. Please, contribute and share the Longevity Cookbook campaign. Let’s defeat aging together!

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Biology and Biology of Aging Resources

We have prepared a list of resources that can help understand biology of aging. We tried to find easy to grasp information sources and compiled a list of lectures, audio courses, popular science books and articles on biology in general and biology of aging in particular. The selected resources probably don’t exhaust the whole picture of aging science, but they shed light on the main ideas and research directions in this area.

For those who have never studied biology systematically, we suggest to take a look at the MIT “Introduction to Biology” course.

These lectures are mainly about different aspects of molecular biology, biochemistry anad genetics. Beside that, the course provides understanding how this knowledge can be applied in real life: in gene engineering and molecular medicine.

A good online course «Useful genetics» from Coursera.org addresses genetics and its applications.

One of the lectures from this course is by the way about genetics of aging.

“Frontiers in biomedical engineering” course was presented at Yale University and is available on Youtube.

Additionally you can listen to the audio course on molecular and cell biology from UC Berkeley.

Now let’s talk about biology of aging. For starters you can read a popular science article in National Geographic titled «Longevity». It provides the most general knowledge about the genetic mechanisms that regulate aging. A very detailed description of aging on various levels (from molecular to whole organism) is provided in the books «Biology of Aging» by Roger B. McDonald and «Biology of Aging: Observations and Principles» by Robert Arking. There was a couse at MIT on biology of aging, age-related diseases and potential therapies, “The Biology of Aging: Age-Related Diseases and Interventions”, the website provides the summary. The topics that are mentioned in this course generally depict the main research avenues in biology of aging and the can be used as reference points for self studying.

Moreover, we have put together a list of lectures given by prominent scientists that provide a look at aging from different perspectives. The lecture by Vadim Gladyshev is devoted to the topic of various theories of aging – “Molecular Cause of Aging”.

Noteworthy are the lectured by the leading scientists from Stanford University, Thomas Rando and Anne Brunet  -“Longevity and Aging in Humans”

and by Janko Nikolich-Zugich from Arizona State University – “The Biology of Aging: Why Our Bodies Grow Old”

Nir Barzilai, Director of Aging Research Institute at Albert Einstein College of Medicine gave a lecture on genes, facilitating longevity in humans – “The role of protective genes in the exceptional longevity of humans” by Nir Barzilai .

Konstantin Khrapko talks about the role of mitochondia in aging – “Mitochondrial Genetics of Aging”.

Judy Campisi, professor at the Buck Institute for Research onaging, gave a talk on the relationship of cancer and cell senescence – “Cancer and aging: Rival demons”

Additionally, several lectures are about the aging of the brain – “The Aging Brain: Learning, Memory, and Wisdom,” by John Gabrieli.

and «The Aging of the Brain» by Carol A. Barnes

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Senescent Cells Removal Alleviates Age-Related Pathologies

Getting rid of senescent cells improves health in mice. In the picture we can see two mice of the same age, however one of them has lordokyphosis (the obvious problem with the spine), sarcopenia (loss of muscle mass), cataracts and other age-related pathologies. The other one has got its senescent cells removed by the group of researchers led by Darren J. Baker and Jan M. van Deursen at the Mayo Clinic in Rochester, Minnesota. Senescent cells are the aged cells that stopped dividing, but still secreting tons of various molecules into their environment. A lot of those molecules are harmful. The hypothesis expressed by Dr. Judith Campisi was that these senescent cells contribute to aging processes in our tissues and are the cause of aging and pathologies. In the paper published in Nature Journal the link between the presence of senescent cells and age-related diseases was established. Researchers took a rapidly aging strain of mice and genetically changed them in a way to be able to selectively kill these senescent cells that expressed the p16Ink4a gene by triggering apoptosis (cell suicide). Senescent cells were removed only from the skeletal muscles, fat tissue and lens. As a result there was a significant reduction in aging pathologies in these tissues. Unfortunately, there was no difference in life span, but researchers believe it was because the main reason of death in this strain is heart failure. Senescent cells were not removed from the arteries walls and cardiac muscles, so this may be the reason why both groups of mice live the same amount of time. It would be very interesting to see if lifespan will be increased if researchers remove senescent cells from all of the tissues.

Read the story about senescent cells removal in NY Times

Read the original paper

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Positioning of the radical life extension idea

positioning, life extension, radical life extension, immortalism, transhumanism, fighting aging, fight against aging, aging, lifespan increase, healthspan, healthspan increase, rejuvenation, age-related diseases, choice

There are several ways of positioning the ideas of radical life extension:

1. Defeating aging
The main objection here is that this kind of presentation of the problem scares people, since it looks non-scientific. And it does this especially to people who are in no way involved with science or to those who have never dealt with studying the mechanisms of aging.

2. Controlling aging

3. Fighting age-related pathologies
I belive if you put it this way, the message looks wrong. It’s medicine that fights diseases. We propose to fight the causes.

4. Body rejuvenation
Well, this formulation kind of associates with folk-medicine.

5. Getting rid of age-related changes in an organism
Some people, especially in the western world, believe this presentation of the issue to be the optimal one. It doesn’t seem that way to me, though. Maybe science will follow the path of improving the regenerative potential of the body. This formulation sounds more acceptable, but I’m afraid it doesn’t really motivate people to make a personal effert to solve the problem.

6. Immortalism
The majority of people state that this word sounds scary and not clear. Same thing about immortality. But on the other hand, people who support the ideas of immortalism are much more motivated to actually achieve the result.

7. Transhumanism
Oh, this one sounds even more scary. But as a matter of fact, it’s about maximum possible lifespan extension and maximum possible improvement of one’s abilities. Maybe the term should be different; maybe it’d be better to go back to the word “humanism,” but I’m not sure.

8. Healthspan increase
Sounds really formal and official, for governmental use. And it’s absolutely not clear that we speak not about jogging, but about research in genetics, biochemistry, biophysics, etc.

9. Radical life extension

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Filed under Immortalism, Life Extension, Transhumanism