Tag Archives: anti-aging

Longevity Cookbook Indiegogo Launch Party

longevity cookbook indiegogo launch party5 reasons why you should invite your friends to the Longevity Cookbook Indiegogo Launch Party:

1. Do you want your friends to have better and longer lives? Take care of them! Let them know that they can extend their lives and the lives of many people around them.
2. To slow down and eventually defeat aging people should unite. Longevity Cookbook Party is an amazing opportunity to meet like-minded people, think of new projects together and have fun.
3. Longevity Cookbook is the strategy of defeating aging. We are launching a project that is going to change everything. Participate in this historic event! Our book will save millions of lives because we will provide scientifically proven information about how to preserve your life.
4. Often people don’t know how to help the cause of longevity. Now there is a clear answer! It is crowdfunding for Longevity Cookbook.
5. And photos of course! We will have tons of cool pictures taken from the Party!

Reposting this is making a contribution to an action of peace, goodness and fairness.

I am looking forward to seeing everybody on May 14 at Mighty club in San Francisco at 119 Utah street!

RSVP – https://www.facebook.com/events/1750304398529385/

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Hollywood Must Turn Its Head to Personalized Longevity Science instead of Anti-Aging Pseudoremedies

This attention-worthy article in The Hollywood Reporter signals that Hollywood people are ready and willing to do something about their longevity. The article mentions hormone replacement therapy, different check-ups and other things available in California, however completely misses 99% of what actually can be done about aging – science. Why doesn’t the author talk about the work done at the Buck Institute for Research on Aging, USC, UCLA and Stanford University?

People are looking for a ready solution, something that they can do today, and mistakenly dismiss science completely, because they think it is too far away for being applied to them. Well, this is a wrong approach. Science can be applied to a particular person’s health. It is called personalized science. It means that we can treat a given person’s health as a scientific task. There already are several examples for personalized science in action.

Martine Rothblatt created a pharma company to invent a cure for her daughter Jenesis’s rare disease primary pulmonary hypertension, she hired the best researcher in that area back in 1996 and they created the pill that significantly improved the well-being of these patients including her daughter. This venture turned out to be quite profitable as well as being life-saving.

The other example is Michael Snyder and his recent attempt to analyze “omits” data about himself. Dr. Snyder is the Head of Genetics Department at Stanford University. He was measuring 40,000 parameters and by analyzing all this health data, his team managed to spot the onset of type 2 diabetes way earlier than he would have noticed it using conventional methods.

So, there is so much that can be done using scientific approach to health. It is not cheap, and at this point of time this kind of personalized science is for the wealthy, however the Hollywood Reporter article is exactly for this kind of crowd, it describes quite expensive health services that don’t necessarily yield results. I believe the message that science is a very powerful tool to increase longevity has to be brought to the general public, especially here in California where a great number of outstanding aging research facilities are situated.

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Newborn heart muscle can grow back by itself

Researchers at UT Southwestern Medical Center have discovered that the mammalian newborn heart can heal itself completely.

Researchers, working with mice, found that a portion of the heart removed during the first week after birth grew back wholly and correctly – as if nothing had happened.

“This is an important step in our search for a cure for heart disease, the No. 1 killer in the developed world,” said Dr. Hesham Sadek, assistant professor of internal medicine and senior author of the study available online in the Feb. 25 issue of Science. “We found that the heart of newborn mammals can fix itself; it just forgets how as it gets older. The challenge now is to find a way to remind the adult heart how to fix itself again.”

Previous research has demonstrated that the lower organisms, like some fish and amphibians, that can regrow fins and tails, can also regrow portions of their hearts after injury.

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Filed under Life Extension, Regenerative medicine, Tissue rejuvenation

Methuselah Foundation needs your input

From the Methuselah Foundation Blog, a message from founder and CEO Dave Gobel: “It has been a while since I sent you an update and there is plenty of good news to share as we work together towards longevity. I also want your input as we make plans for the coming year. … Methuselah Foundation has successfully promoted the extension of healthy human life – the science of aging has gained acceptance and broad-based support thanks to your ongoing contributions. Now we are strongly supporting science that will lead to tissue engineering and organ regeneration. We will be the catalyst to speed up the development of organ replacement. … I am continually delving into every area of science, the work being done in universities, labs and biotech companies, to see the latest research and how it might contribute to longer life. I am convinced that there are many viable solutions but we, uniquely, are in a position to move them to a practical place. With this mission in mind we created the NewOrgan Prize. Based on our success with the Mprize, we anticipate this new prize will accelerate the rate of research and bring us closer to practical solutions. … We must continue to accelerate practical scientific solutions related to aging. You and I – not just our children and grandchildren – should benefit from the advances in tissue engineering that are already on the table. This is why I need your input. We are contemplating a number of initiatives in support of this drive but we want to have the greatest possible impact. I would appreciate your thoughts and suggestions. Please continue reading and I believe you will have a clear understanding of the potential and, hopefully, will have some thoughts to share.”

You can read the rest of the post and if you have opinions and good ideas, send them to the Foundation.

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Filed under Life Extension

Here is the Research Needed to Combat Aging

It is more or less clear what we should do in order to defeat aging. I’d like to bring to your attention a research plan in genetic and epigentic regulation. The author is Professor Alexey Moskalev. But there’s a question to which I don’t know the answer – how can one get the funding?

Download pdf – Methods of studying and interventions in genetic and epigenetic processes


Filed under Funding, Genetics

President of Kazakhstan urges scientists to unlock the secret to immortality

70-year-old Kazakh President Nursultan Nazarbaev appears to have a keen interest in radical life extension and longevity research. Nazarbaev has repeatedly used his post as president to call for renewed research into medical immortality. Recently in a speech to students marking the opening of Nazarbaev University in Astana, Nazarbaev spoke of the need for research on topics such as: “rejuvenation of the organism…the human genome…production of human tissue…the creation of gene-based medicines.”

Earlier this year, Nazarbaev was granted powers that will, in effect, allow him to serve as Kazakhstan’s president for life, whether formally in office or not. Two months ago, Roman Kim, a Kazakhstani of Korean descent and a delegate to Kazakhstan’s People’s Assembly, proposed that Nazarbaev should stay in power until at least 2020.

“As for the medicine of the future, people of my age are really hoping all of this will happen as soon as possible,” Nazarbaev said.

It seems like aging is something the ruler has been worried about for a while. In October of 2009 he was quoted as saying:

“One important subject is anti-aging, or the study of prolongation of life,” he told an audience at the Kazakh national university in Almaty. “However difficult such investigations are, these questions must be resolved sooner or later. Why shouldn’t our scientists take on this task? Would it not inspire our Kazakh youth who are now living through the great moments of passion?”

Also in 2009 at a government science committee meeting he said: “Anti-aging medicine, natural rejuvenation, immortality, that’s what people are studying these days. Those who do are the most successful states in the world – those who don’t will get left on the sidelines.”

Read more about this story from CBS News

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Filed under genomics, Immortalism, Life Extension

Don’t most businessmen want to live?

Funding of life extension research is extremely close to zero. It lookes like there’s just a couple of men interested in their own lives. The rest seems to want to die. One of those few smart businessmen, Jason Hope announced a half a million dollar donation to the SENS Foundation, a California-based non-profit organization that works to develop, promote and ensure widespread access to rejuvenation biotechnologies which comprehensively address age-related diseases.

“I have had great interest in the SENS Foundation and Dr. Aubrey de Grey’s work for some time now.  I believe their work is essential to the advancement of human medicine and their approach to the overall problem of human aging and its associated diseases (Alzheimer’s, Atherosclerosis, Diabetes, etc.) is the only way to go.  Their work and the work of others that they support will drive the complete redefinition and reshaping of the healthcare, pharmaceutical, and biotech industries as we know them today.  The advancement of rejuvenation biotechnologies is not only extremely important, but it is the future. I am honored to support the SENS Foundation in its efforts, and hope my support helps drive faster results for all of humanity,” said Jason Hope.

The donation was announced by SENS Foundation CEO, Mike Kope, at Tuesday’s ‘Breakthrough Philanthropy’ event hosted by the Thiel Foundation, in the Palace of Fine Arts in San Francisco – an event that was covered here on my blog this past week.

“We need to create an entirely new biotech industry. That’s why we created SENS Foundation: to be a credible catalyst for change; to be a public research and outreach organization devoted to the creation of a new field- rejuvenation biotechnology.  To that end, we are proud that our projects are capturing the imaginations of top tier collaborators in biotech and regenerative medicine.  Jason Hope’s donation is a major contribution, enabling us to build on our existing collaborations in 2011, and accelerating our progress in the fight against age-related disease,” said Mike Kope

“I enjoyed hearing a lot of great presentations at the Breakthrough Philanthropy event,” said Thiel Foundation chairman Peter Thiel. “But for me, the highlight of the whole evening was hearing about Jason’s bold commitment to defeating aging.”

SENS Foundation CSO, Aubrey de Grey, described the use to which Hope’s donation will be put:

“Arteriosclerosis – hardening of the arteries – is the main cause of increased blood pressure (hypertension) in the elderly, which in turn exacerbates major aspects of aging such as diabetes. It is caused largely by the unwanted accumulation of molecular bonds between the proteins that hold the cells of the artery in place – the extracellular matrix. The same process causes long-sightedness (presbyopia) and contributes to skin aging. I am delighted that Jason’s donation will fund our work on the pharmacological breaking of these unwanted molecular bonds, and the restoration of elasticity to the body’s extracellular matrix.”

Read Mike Kope’s announcement at Tuesday’s ‘Breakthrough Philanthropy’ event and to learn more about SENS Foundation


Filed under Funding, Life Extension, Regenerative medicine

Artificial muscles being developed at NASA’s Jet Propulsion Laboratory

Electroactive polymers that bend, stretch and shrink like human muscles when an electric current passes through them is what’s being engineered by a science research team at NASA’s JPL. The hope is that these artificial muscles would be able to work in conjunction with artificial intelligence to drive robotic arms.

The  NASA team is being led by Senior Research Scientist Yoseph Bar-Cohen who in order to raise awareness of the field, promoted an arm-wrestling challenge to the international scientific and engineering communities in 1999. Bar-Cohen stated “I chose to focus on arm-wrestling with humans in order to have our muscles as a basis for comparing performance and capability.  Success in this will advance the field of medicine, including prostheses that can be very effective. We may soon see artificial muscles replace damaged human muscles.”

Bionic limbs and bionic people with artificial muscles – as well as robots that look and operate like real animals and humans—are not beyond his vision of the future – or ours. “One day we may see a disabled person literally running to the grocery store using this technology,” he says. “Other short-term goals include refreshable Braille displays and realistic, biologically inspired robots.”

Read more about the study and how this new technology could benefit a wide variety of applications in the medical field

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Filed under Immortalism

The FDA Needs to Rethink Aging

I wanted to share an interesting perspective by statistician Gary Liberson, PhD. He recently published some valid points on the present system of FDA licensing and the difficulty that companies face in finding an economic justification for longevity research without seeking a specific disease.

According to Liberson, the problem lies with the FDA approval system that requires a pharmaceutical company show three things: (1) a mechanism of action (i.e., identify why a drug works), (2) safety and (3) efficacy in managing a measurable biologic end point associated with a disease. This last condition, according to Liberson is a  problem.

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Filed under Biomarkers, Mechanisms of aging

It’s Too Early to Be Joyful

U.S. scientists at the Dana-Farber Cancer Institute in Boston say they have partially reversed age-related degeneration in mice through a controllable telomerase gene – this led to new brain and testes growth, improved fertility and the return of lost thinking skills.

I have discussed the telomerase gene and aging in previous posts and how research has indicated how low levels of telomerase leads to deterioration and shortening of the telomeres, resulting in physical and mental decline. Well the team at Dana-Farber developed mice with a controllable telomerase gene.  Creating mice with a controllable telomerase gene allowed these scientists to create prematurely aged mice. This control also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging.

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Filed under Mechanisms of aging