Tag Archives: endosymbiotic theory

Mitochondria and its role in aging

Mitochondria

Today was an amazing lecture by Dr. David Lee about mitochondria and its role in aging. Dr. Lee started with an overview of what mitochondria is and what it does. You may have heard that the origin of mitochondria is bacteria that was engulfed by the cell early in the course of evolution. There are several things that back this «endosymbioic» theory:

  1. Mitochondria self-replicates
  2. It has two membranes
  3. It has its own independent DNA
  4. The ribosomes are similar to those of bacteria
  5. The sizes are very alike
  6. Mitochondrial DNA shares similar to bacterial structural motifs
  7. The inner mitochondria membrane has a more bacterial-like lipid composition

Mitochondria vary from 0.5 to 10 micrometers in size. Their outer membrane is freely permeable, it let’s in and out proteins less than 5000 daltons. The inner membrane, however is tightly regulated, nothing gets in or out without the special transport. Inner membrane forms cristae that curve inside to maximize the surface for energy production.

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Filed under Biology of Aging