Tag Archives: gene therapy

Longevity Gene Therapy – Updated Projects

While discussing the longevity gene therapy project we encountered various questions and observations that prompted us to broaden the project and slightly change it. Generally, all the comments can be reduced into 5 main points:

  1. You need to enlarge the list of therapeutic genes by adding to it this and that.
  2. You want to use too many genes; therefore you need to make the project simpler by keeping only the most effective genes
  3. If you apply all the genes at the same time, some of them may cancel out the effects of other genes.
  4. Will it be safe to use viral vectors to deliver genetic constructs?
  5. How safe are therapeutic genes for the body?

Some of the observations were of completely opposite nature, so we decided to do 2 versions of the project. One of them is for aging geneticists. In it we almost double the list of the genes extending lifespan. This project will allow testing many poorly studied genes, but promising in terms of aging. Besides, some unexpected results can be obtained, which is always valuable.

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Popular Lectures on Gene Therapy

We have put together a list of popular science video lectures on gene therapy – one of the most promising molecular medicine directions. What makes this approach different is that nucleic acid molecules, DNA and RNA, are used as therapeutic agents.

To have the most general idea about the principles of gene therapy you can watch this video

The lecture by Dr. Hans-Peter Kiem from Fred Hutchinson Cancer Research Center at University of Washington provides more detailed information about the main approaches utilized by gene therapy, nucleic acid delivery methods into the cells and also the diseases that use gene therapy for treatment

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Longevity Gene Therapy Is the Best Way to Defeat Aging

Схема-для-блога

Gene engineering is the most powerful existing tool for life extension. Mutations in certain genes result in up to 10-fold increase in nematode lifespan and in up to 2-fold increase in a mouse life expectancy. Gene therapy represents a unique tool to transfer achievements of gene engineering into medicine. This approach has already been proven successful for treatment of numerous diseases, in particular those of genetic and multigenic nature. More than 2000 clinical trials have been launched to date.

We propose developing a gene therapy that will radically extend lifespan. Genes that promote longevity of model animals will be used as therapeutic agents. We will manipulate not a single gene, but several aging mechanisms simultaneously. A combination of different approaches may lead to an additive or even a synergistic effect, resulting in a very long life expectancy. For this purpose, an animal will be affected by a set of genes that contribute to longevity. In addition, a gene therapy of all major age-related pathologies will be developed to improve the functioning of individual organs and tissues in old age. As a result, we will develop a comprehensive treatment that will not only dramatically extend lifespan, but will also prevent the decrepitude of the body. Experiments will be conducted in old mice. Thus, in case of success, the developed method of aging treatment can be quickly moved to clinical trials.

The goal of the project is to develop a complex gene therapy that will drastically increase mouse lifespan and prevent tissue pathology in old age, coupled with the safety assessment of the treatment.

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What Should Be Done to Achieve Radical Life Extension?

Crowd

Theoretically the problem is already solved. It is now quite obvious what kind of research should be done for life extension. For example, testing various combinations of different things that extend lifespan in old mice. Particularly important is longevity gene therapy development.

Delivering 5-7 gene vectors simultaneously carrying longevity-associated genes into an old animal could prove to be quite beneficial, because similar approach already works.

It is also clear that there are several experiments in the area of therapeutic cloning that should be done immediately.

There are about 20 other research directions in the area of radical life extension. I’d like to just also mention implementing aging diagnostics into clinical practice.

There are approximately 50 labs in the states that move into the right direction. They could do much more if they had more money.

Well, it’s all about the money, but not really big money.

Transhumanists from all over the world have been trying to solve the mystery of how to secure funding for reaching physical immortality. The very development of science leads towards it, but this process is too slow, a lot of people may not make it in time. Our goal is to accelerate.

Right now it has become obvious how to find the money for radical life extension. It’s crowdfunding. 200-300 campaigns need to be created on various crowdfunding platforms on the topics of fighting aging and regenerative medicine.

Of course, we may not be able to find the necessary amounts of money right away, but we will be able to delineate the scope of goals, most importantly not using just the general words, but particular scientists, labs and research plans.

Even by only preparing the campaigns we will influence the society by once again providing the proof of the possibility of significant life extension. Unfortunately, molecular biology is not part of an every day’s person background. We will make people more educated, show them how diseases originate, progress, and how they relate to aging. We will also tell the people what can be done.

While working on the crowdfunding campaigns we will mobilize our supporters by giving them a concrete tool and a plan of action. Fighting aging crowdfunding will become a very powerful transhumanist organizational solution.

In the end we will gather the money, implement our projects and win!

If you are interested in bringing this plan to live, let’s collaborate. Every single project requires a manager, analyst, scientist, director, operator, a guy who owns a car and a guy who writes a lot about this on the Internet. There is work for everybody, so let’s do this.

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Successful Results of Aging Research According to the Washington Post

It is always nice to see articles about fighting aging in the major press sources. This article in Washington Post sums the most promising results in aging research so far. The most successful interventions include caloric restriction, metformin, acarbose, rapamycin, genetic modification and GDF11/parabiosis. I would say that the author has left out some things like melatonin and aspirin, for example. Also I wouldn’t suggest parabiosis as an intervention, sure it’s good for the old, but what about the young organisms? Some of their biological parameters become worse as a result of parabiosis. We wouldn’t want that effect in people, would we?)) However, pharmacological intervention based on the GDF11 is another thing that may work.

I was very pleased to see that gene therapy was among the proposed solutions. In my opinion it has enormous potential. We now know about 100 longevity-associated genes. Why not use gene therapy to either bring these genes into the organism, or increase their efficiency if they already exist. We could try various combinations of those genes and maybe the combinations can lead to synergistic rather than additive effect. But who am I kidding, additive effect would also be amazing if proven safe and efficient in humans.

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