Tag Archives: life extension

Longevity Cookbook Indiegogo Campaign Is the Most Effective Step You Can Take towards Your Longevity

longevity cookbook, health, rejuvenation, aging, cookbook, healthy eating

Something amazing has happened! We have launched our Longevity Cookbook Indiegogo Campaign.

Aging steals away your most valuable resource: time. The Longevity Cookbook is a strategy guide to help you get more time to experience the joy from everything that you like in life. Take yourself on a journey starting with nutrients and exercise regimes that goes on to exploring the usage of genetically modified symbiotic organisms and using gene therapy to boost your own longevity.

Contributing to ‪#LongevityCookbook‬ is the best way you can spend your money, because we are fighting for your life. Please, contribute and share the Longevity Cookbook campaign. Let’s defeat aging together!

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Discipline Is More Powerful than Motivation

maria konovalenko lab longevity aging research

I know a bunch of people who support life extension, but they are very busy. They are going to first of all deal with their stuff and only then become involved in anything related to longevity. It’s just that there is always stuff to do every day. Meanwhile, life is passing by. We may be simply late. Late by 10 years, by 1 year, by only 1 day. There can be no situation more stupid than being late to buy «my life» ticket. There is so few people in our field. To fight aging you don’t really need motivation, you need discipline. You have to just force yourself. Simply force yourself.

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Transhumanism Strategy

We’ve put together the survey on transhumanism strategy to reveal the inner discussion inside the transhumanist movement. Our goal is to inspire the people to act.

We believe the greatest sin in our field is wishful thinking. It’s when a person is saying that it would be good to do something, like for instance, to shoot a viral video, but at the same time this person is not doing anything. His or hers advice has to be implemented in real life somehow on its own.

We also tried to get away from discussing whether it’s going to be boring to live, what about overpopulation, and whether we should argue with nature or not. We can’t be talking about this nonsense forever.

We will take the liberty of commenting on the obtained results from 223 respondents and share our own opinion on the proposed questions.

58% think a global movement is needed. I suppose we agree with it, but it’s not necessary that right now there have to be a lot of people. It is more important that the people understand the situation and the goals of transhumanism and are ready to act.

20% believe that the cure for aging can only be created as a non-profit project, and 80% think not necessarily. Our position is that only a non-profit initiative can achieve significant deceleration of aging. We’ve witnessed tens of commercial projects in life extension and every time the idea to earn money wins over the idea of living longer. Radical life extension idea is extremely complicated and burdening it with making money overcomplicates everything.

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What Should Be Done to Achieve Radical Life Extension?

Crowd

Theoretically the problem is already solved. It is now quite obvious what kind of research should be done for life extension. For example, testing various combinations of different things that extend lifespan in old mice. Particularly important is longevity gene therapy development.

Delivering 5-7 gene vectors simultaneously carrying longevity-associated genes into an old animal could prove to be quite beneficial, because similar approach already works.

It is also clear that there are several experiments in the area of therapeutic cloning that should be done immediately.

There are about 20 other research directions in the area of radical life extension. I’d like to just also mention implementing aging diagnostics into clinical practice.

There are approximately 50 labs in the states that move into the right direction. They could do much more if they had more money.

Well, it’s all about the money, but not really big money.

Transhumanists from all over the world have been trying to solve the mystery of how to secure funding for reaching physical immortality. The very development of science leads towards it, but this process is too slow, a lot of people may not make it in time. Our goal is to accelerate.

Right now it has become obvious how to find the money for radical life extension. It’s crowdfunding. 200-300 campaigns need to be created on various crowdfunding platforms on the topics of fighting aging and regenerative medicine.

Of course, we may not be able to find the necessary amounts of money right away, but we will be able to delineate the scope of goals, most importantly not using just the general words, but particular scientists, labs and research plans.

Even by only preparing the campaigns we will influence the society by once again providing the proof of the possibility of significant life extension. Unfortunately, molecular biology is not part of an every day’s person background. We will make people more educated, show them how diseases originate, progress, and how they relate to aging. We will also tell the people what can be done.

While working on the crowdfunding campaigns we will mobilize our supporters by giving them a concrete tool and a plan of action. Fighting aging crowdfunding will become a very powerful transhumanist organizational solution.

In the end we will gather the money, implement our projects and win!

If you are interested in bringing this plan to live, let’s collaborate. Every single project requires a manager, analyst, scientist, director, operator, a guy who owns a car and a guy who writes a lot about this on the Internet. There is work for everybody, so let’s do this.

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Life Extension is a Political Task

Sooner or later the human life extension problem, the task of achieving immortality will become the main issue of government policies in developed countries of the world. This will happen on its own because of the exponential growth of technologies.

At some point of time immortality will become the main political question.

This is inevitable. 

Nevertheless, let’s make this process faster to save millions of lives. In order to make this leap towards human radical life extension, political will is needed.

Without it there is no money for new research, no laws permitting the most radical experiments (cloning and transplanting a mammal’s head), there is no fast approval of new therapeutics. There is no proper interest.

We consider the gay community fighting for anti-AIDS drugs development against FDA an excellent example of political struggle. It is pictured in the How to survive the plague movie and its trailer.

Here we see the main signs of successful political struggle – large amounts of people uniting, heating of emotions, street actions, using speech, music, slogans and any other features. Vigor in being ready to fight for the right to live.

This is a spectacular example to follow. A call for action to fight for lifespan increase.

The majority of transhumanist efforts were dedicated to trying to persuade the billionaires. At large, this strategy failed. Billionaires are billionaires because they love money more than their own lives.

The major result here is Google creating Calico company. Calico’s budget was announced to be several hundreds of million dollars. However, it is still unclear what Calico will be doing. The research plan wasn’t shared with the public.

There are several reasons why persuading the billionaires failed – their preoccupation with immediate return, their religious beliefs (Steve Jobs), their irrationality and so on.

Therefore, there are only two possible addressees of our message – the government and the people. In a democratic state the policy is defined by the people’s choice, and because of this crowd activity is particularly necessary to influence the state. Moreover, the people can substitute the state. For example, back in the day the government gathered taxes from the people and spent them on various projects, but now the people can do the very same thing using crowdfunding and substitute the government. Although, perhaps, in the future we will see transhumanist parties in parliaments.

Various public actions can influence government policy. It is our task to prepare actions in favor of life extension. An idea acquired by the masses is material, Lenin wrote.

If a given idea has 20 million followers, it doesn’t need a state to win. It has already won. It can form an alternative system of decision making on the Internet, i.e. create the crowd-power.

Radical life extension is the strongest idea in the history of mankind. The Pirate party and the Green party may serve as an example of how the international life extension party will be created. First of all, there has to be a circle of people who share the same value, and separate flamboyant actions that highlight this value. Just like Greenpeace performed this action when they sailed to the island where the nuclear testing was about to take place.

However we are aware that radical life extension idea still hasn’t got enough followers, and public actions are needed to attract new supporters, because actionism is also quite fascinating. Maybe we should float 400 coffins into the Hudson River so that people will see with their own eyes how many people die in New York every day.

Another way of using the power of the crowd is crowdfunding of scientific experiments.

And it’s important to say that there are such experiments that possess the power of political acts, meaning they extend the limits of what’s possible and set the direction of further movement.

It so happens when the first step in some activity sets the direction, for example when a person gets admitted to university for particular major, this defines his movement on the professional ladder – whether he will become an economist or a dentist, a marine or an AI developer. Yes, options are possible, but the first actions triggers the following ones.

We have to find exactly this kind of solutions in our field.

For example, transplanting a head from one mammal to another will become the discovery of the whole area of research, but right now this procedure is not permitted because of the pseudoethical beliefs in the majority of the countries in the world. Today the most obscurant people with cave world view bloviate about bioethics.

What kind of experiments are those?

Restoring the activity in brain samples

One of the main arguments against cryonics is that it’s unclear whether the memory of the person will survive the freezing. However, it is well known that nematode worms survive the freezing in liquid nitrogen quite well, meaning separate neurons can survive the freezing. The question is if we teach the worm do something and cryopreserve it, will the acquired memory be intact after we warm it up? If so, then we will be able to do this experiment in more complicated organisms. If not, then… we still should move to more complicated models and study the requirements for memory preserving.

Implementing aging diagnostics in the clinical setting

If we are able to do aging diagnostics, we will be able to measure the efficacy of anti-aging drugs much faster than watching whole generations of humans age, meaning we will see the effects within our lifetime. This is how aging will stop being a black box and will become a quantitative and changeable parameter.

Testing various substances and therapies on longevity will stop being some shaman magic and will gain solid scientific basis. Drug development will become very rapid and significant human life extension will be achieved.

Life extension in old mice using longevity associated genes

We can use genetic vectors and other technologies to insert various genes associated with longevity in adult mice, and we can select the combinations of those genes that will significantly increase lifespan. This will pave the way to creating human longevity genetic engineering.

Let’s do those things to a rat that make the naked mole rat negligibly senescent.

Transplantation of therapeutically cloned organs

This experiment will illustrate the potential of therapeutic cloning and will open new opportunities in regenerative medicine.

Sustaining viability of a mammal’s head for more than 1 year outside the body

If we are able to sustain viability of a head outside the body, this will open up the new possibility for extending life in terminally ill people, including the transition to using the completely artificial body.

Working model of the nematode worm’s brain

It we are able to simulate the operations of the 300 neurons of the nematode and reconstruct its behavior, then we will prove the sufficiency of our knowledge for more complicated objects.

Applying AI for diagnostics using tens of thousands of parameters

AI can become a powerful player in healthcare – if we have the detailed information about our health, we will be able to easily prevent any kind of disorders on very early stages of their development. By doing so we will significantly reduce the risk of death. In the end AI will not only act as a physician, but it will also conduct scientific experiments and will guarantee human life, health and immortality.

Based on everything said I propose collaboration on the following three things:

First of all, crowdfunding of basic scientific research. There is a new service that would connect the public and medical research – LabCures. It will allow everyone to fund whichever research in life-sciences that they like.

Secondly, we propose to join the Longevity Party group on Facebook and use this resource for organizing street actions, demonstrations, graffiti and so on.

Thirdly, I invite everyone to come to our Genetics of Aging and Longevity conference in Sochi on April 6-10, 2014. The world’s leading aging researchers will gather there to discuss the latest research highlights in the field of life extension. We will be very happy to see volunteers on our conference.

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Robert Shmookler Reis on Fighting Aging Approaches and Role of Basic Science

Dr. Reis talks about the main trends in longevity research, potential for creation life extension therapies in the nearest future, his favorite genes, preferable ratio of basic to applied research funding and the overall hurdles of aging research field.

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Dark Matter of Transhumanism

Enjoy watching my talk at Stanford Advancing Humanity Symposium. In this talk I am sharing our wonder about why haven’t the ideas of life extension won. It is not clear why isn’t every person on Earth concerned with their longevity. There are several serious reasons that I mention in my presentation, but even all of them combined don’t give the answer to this question. I am also looking at different possible scenarios of how the extending longevity ideas could rise to power. I’d like to know which scenarios you think is the most likely one. Please, share your thoughts.

Here’re the slides.

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Thomas Perls – Increasing Genetic Influence Upon Exceptional Longevity with Older and Older Ages

Here’s a talk by Dr. Thomas Perls at the 2nd Genetics of Aging and Longevity Conference. Dr. Thomas Perls, MD, MPH, Associate Professor, Boston University Medical Center,  is the founder and director of the New England Centenarian Study, the largest study of centenarians in the world. A significant portion of the study is devoted to understanding why centenarians delay or escape Alzheimer’s disease and other brain disorders.

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Second Transhumanist Political Meeting Took Place in Moscow

The Second Transhumanist Political Meeting took place on Saturday, September 22, 2012 in the very center of Moscow in Revolution Square right opposite the famous Bolshoi Theater. For the secont time Russian transhumanists went to the streets and declaired their demands, which are – life and youth for everyone, development of new biomedical technologies and development of life extension therapies. The meeting was organized by the Russian Transhumanist Movement. I loved the atmosphere. It’s such a pleasure to be surrounded by like-minded people, who understand the importance of common actions aimed like this one. The meeting was aimed at publicly stating that we need our lives to be protected and extended. We demanded more money to be dedicated to research aimed at eliminating aging and life extension. In this picture Mikhail Batin is saying a couple of words about his new transhumanist book Futurology that he co-authored with Alexei Turchin.

The poster says: “250 years of life for everyone”

“We are against death!”

Posters from left to right: “Eternal youth to the masses”, “People must live” and “For cryonics”.

Alexei Turchin, expert in global risks, is showing Anna Arlanova, actress, the book Futurology, which can be thought of as a transhumanist text book.

Dr. Yury Pichugin is advocating that cryonics must be recognized as a credible scientific field, that holds a lot of potential for the humanity and that more money has to be spent on research in the area of cryobiology.

Daria Khalturina, lobbying expert, is signing the petition to increase funding for research aimed at life extension addressed to the Russian authorities.

“The right to live is the main human right”

“Overpopulation is a myth”, “Protect our right for life!”

“I want to become a Genetically Modified Organism”

“We are for regenerative medicine” and “The retired must live”.

“I want to extend youth to 150 years”

 

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Do you Want to Be Immortal? Really? – Yes, Really.

In this recent article the Huffington Post author George Young asks a question if we really want to be immortal. He tells the readers about Igor Vishev, Russian philosopher, who believes that the first people to become immortal are likely to be already born today. Igor Vishev is the follower of Russian cosmists, such as Nikolai Fedorov, Vladimir Vernadsky and Konstantin Tsiolkovsky.

From Fedorov on, a main cosmist idea has been to overcome death. For Fedorov individual immortality was not sufficient; our ultimate task was to bring back to life all humans who had ever lived. A devout if eccentric Christian, Fedorov viewed the resurrection as a human task, the Christ-like duty of the sons and daughters of humanity to restore life to those from whom it had been taken. Children would use future scientific technology to resurrect their parents, who in turn would resurrect theirs, all the way back to Adam and Eve.

And then after telling the story of Russian cosmists the author of the article simply becomes blind all of a sudden and falls into the trap built by shortsightedness and inability to think rationally. He writes:

The important question now may not be whether remaking ourselves and our universe to eliminate limits to present life is possible, but whether it is desirable. For centuries poets have intuited profound value in the mystery of death. As Shakespeare tells us in Sonnet 73, death gives life meaning, and love grows more strong for that “which thou must leave ere long.” Or, as Wallace Stevens wrote in “Sunday Morning,” “Death is the mother of beauty.” Could many of our best intangibles be lost in the transition from human to “transhuman”?

Shakespeare knew nothing about antibiotics and resuscitation. He had no choice but to accept death, otherwise it would be just too hard to live knowing that death is the worst, most horrible thing that can happen. It is so much easier to attribute death some meaning or even positive qualities. It means that we don’t have to fight it or fear it, death is normal, good even and we can get back to our everyday routine. But the reality is 100% different. Death is not the mother of beauty. Death is the mother of worms, eating your rotting body. Death makes your life worth nothing. And it doesn’t matter if you leave your work behind – you won’t care, because there will be no you. Just like every dying pharaoh would trade all the gold and pyramids he owns for another day of life, every lethally sick person would give everything he owns for the cure, just to live one more day, just to breathe for a bit longer.

The question of what death is and how or whether we should attempt to eliminate it won’t be settled here, or anywhere, anytime soon. But if Igor Vishev is right, someone alive today — certainly not the one writing these words, but maybe someone reading them — may be around long enough to know the answer.

I understand why George Young is so against immortality – he doesn’t believe he will be able to use life extension technologies. He is a senior citizen at the moment and this makes him pessimistic. His mind wants to protect him from the frightening thought that some people will become immortal, forever young maybe, but not him. So his mind tries to justify death in his own eyes.

But Mr. Young may be wrong in his assumption that he is not going to benefit from life extension technologies. If the existing life extension results are transferred from model animal to humans, he may well have the chance to live for quite some more time. And during this extra time there’s a good chance some new technologies would be developed to prolong his life even more. We don’t know this for sure, but we have to fight for our lives.

The more optimistic and unbiased articles we have about the possibility of life extension, the greater our chances are to eliminate all the age-related diseases and make people live much healthier and, most importantly, much longer lives.

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