Tag Archives: longevity

Discipline Is More Powerful than Motivation

maria konovalenko lab longevity aging research

I know a bunch of people who support life extension, but they are very busy. They are going to first of all deal with their stuff and only then become involved in anything related to longevity. It’s just that there is always stuff to do every day. Meanwhile, life is passing by. We may be simply late. Late by 10 years, by 1 year, by only 1 day. There can be no situation more stupid than being late to buy «my life» ticket. There is so few people in our field. To fight aging you don’t really need motivation, you need discipline. You have to just force yourself. Simply force yourself.

4 Comments

Filed under Life Extension

You Are Invited to Longevity Cookbook Indiegogo Launch Party

4 Comments

Filed under Uncategorized

Longevity Cookbook Indiegogo Launch Party

longevity cookbook indiegogo launch party5 reasons why you should invite your friends to the Longevity Cookbook Indiegogo Launch Party:

1. Do you want your friends to have better and longer lives? Take care of them! Let them know that they can extend their lives and the lives of many people around them.
2. To slow down and eventually defeat aging people should unite. Longevity Cookbook Party is an amazing opportunity to meet like-minded people, think of new projects together and have fun.
3. Longevity Cookbook is the strategy of defeating aging. We are launching a project that is going to change everything. Participate in this historic event! Our book will save millions of lives because we will provide scientifically proven information about how to preserve your life.
4. Often people don’t know how to help the cause of longevity. Now there is a clear answer! It is crowdfunding for Longevity Cookbook.
5. And photos of course! We will have tons of cool pictures taken from the Party!

Reposting this is making a contribution to an action of peace, goodness and fairness.

I am looking forward to seeing everybody on May 14 at Mighty club in San Francisco at 119 Utah street!

RSVP – https://www.facebook.com/events/1750304398529385/

Leave a comment

Filed under Uncategorized

Longevity Cookbook

Longevity cook book menu draft 1

My colleagues and I would like to launch the Longevity Cook Book crowdfunding campaign in upcoming three months.

We would like to raise funding to create a book that will tell the story about what longevity depends on, what processes are going on in our bodies during aging and how they can be slowed down, dieting in the right way, based on the current scientific knowledge. The book will contain the most up-to-date research data on the beneficial properties of various foods, their longevity effects and abilities to prevent different age-related diseases.

Longevity Cook Book will give you the special recipes, developed with the help of professional chefs, on how to cook longevity-boosting dishes from the healthiest ingredients possible.

Besides the recipes, the book will tell you how to “cook” longevity in terms of science. I will explain the existing directions in aging research and the most promising experiments that need to be carried out to make a truly long and healthy life a reality.

Here’s the Longevity Cook Book plan:

Part 1

  • The role of diet in health and longevity. I will describe the diets that increase longevity and prevent age-related pathologies (with proof in humans and model animals)
  • Physiology of nutrition. I will explain how food is digested, how the nutrients are absorbed in the intestines, how they enter blood stream, what they do inside the cells. There will be some pretty pictures to illustrate all of that.
  • Brief and easy-to-understand description of aging mechanisms and the mechanisms of age-related pathologies (like cardiovascular diseases, diabetes, etc.) and how diet can influence those mechanisms

Part 2

Description of the healthy foods including scientific papers, illustrating why they are healthy, and biological mechanisms that those foods influence

Part 3

Longevity Menu. Dishes made with longevity foods cooked the healthiest ways accompanied by pretty pictures of the dishes.

Part 4

“Cooking” longevity. I will describe the main approaches to solving the problem of aging and the most promising experiments.

How do you like the idea? Would you be interested in reading such a book?

For the crowdfunding project to be successful it has to have a powerful start, therefore I’d like to agree on reposting the campaign when it launches in advance.

I call upon everybody to, please, let me know, who would be up to spreading the word about this project when the time comes.

If you have some nice amount of people following you on twitter or other social networks, I’ll be happy to collaborate.

I also welcome advice on how to engage a larger audience. Maybe you have some journalists or bloggers that you know?

I present a draft of a possible layout of one of the pages.

There will be many different icons that tell you various bits of information about the dish. In particular on this page a face means the research on the given type of food was done in humans, a mouse – on mice, a test tube – on cell cultures.

We haven’t yet put together the pictures of aging mechanisms, but we will definitely do it.

38 Comments

Filed under Longevity Cook Book

Judy Campisi – Cancer and Aging: Rival Demons?

Enjoy Judy Campisi’s plenary talk about the relationship between aging and cancer.

Leave a comment

Filed under Conference

Robert Shmookler Reis – Genetic and Lipid-Profile Predictors of Longevity

Enjoy the plenary lecture of Dr. Robert Shmookler Reis about the long-lives worms and biomarkers of aging.

Leave a comment

Filed under Conference

Video from the Genetics of Aging and Longevity Conference – Andrzej Bartke

This is the plenary lecture of Dr, Andrzej Bartke at the Genetics of Aging and Longevity conference that took place in Moscow on April 22-25. I will be posting the upcoming videos of the talks on the Youtube channel of our Foundation. Please, subscribe and enjoy the power of genetics of aging.

Leave a comment

Filed under Conference

Exception to Several Theories of Aging – Why Do Naked Mole Rats Live So Long?

Naked mole-rats (Heterocephalus glaber) are rodents found in the hot tropical regions of the Horn of Africa. When he first described a naked mole-rat in 1842, the famous German naturalist Eduard Rüppell suspected he had encountered a diseased specimen—because the animal had no fur and permanently protruding teeth. Only after several more specimens had been collected did it become apparent that their weird appearance, variously described as resembling saber-toothed sausages or miniature walruses, was normal.
Naked mole-rats live in a maze of underground tunnels that may extend more than a mile in length and as deep as 8 feet beneath the soil surface. Their burrows contain both nest chambers, tended by sterile worker animals, and several toilets, which the animals use religiously to avoid contamination of their living space. To locate the roots, tubers, and small onion-like bulbs they eat, mole-rats must dig through the soil, expanding their tunnels using their chisel-like, ever-growing incisor teeth. They occasionally make an opening to the outside world to kick excavated soil to the surface, where it forms small volcano-shaped mounds—the only aboveground signs of the vast colonies below. Given this strictly subterranean existence, it is not surprising that naked mole-rats have evolved a set of characteristics highly suited to life in dark, dank burrows.

This is how the naked mole rat’s colony looks like. This excellent review in The Scientist by Thomas Park and Rochelle Buffenstein illustrates the complicated lives of these outstanding hairless animals: how they live under the ground in Africa, how they have the breeding Queen and worker-animals (just like the honey bees), how they don’t feel certain kinds of pain, how they are resistant to the lack of oxygen and toxic amounts of carbon dioxide in the air. But the coolest thing about the naked mole rats is that they basically live 9 times more than “they should”:

Although naked mole-rats are the size of a mouse, weighing only about 35–65 grams, in captivity these rodents live 9 times longer. With a recorded maximum lifespan of 32 years, they are the longest-lived rodents known. And remarkably, they appear able to maintain good health for most of their lives. At an age equivalent to a human age of 92 years, naked mole-rats show unchanged levels of activity and metabolic rate, as well as sustained muscle mass, fat mass, bone density, cardiac health, and neuron number.

So not only they are exceptionally long-lived, they are also very active and healthy even in the old age.

Somehow they delay the onset of aging and compress the period of decline into a small fraction of their overall lifespan.

They also have no cancer.

Naked mole rates are exceptions to several theories of aging. For example, the free radical theory states that aging happens, because of the extensive cellular damage from reactive oxygen species. However, naked mole rats show very high levels of oxidative damage from these free radicals and still their cells are perfectly functioning for years and years. Another hypothesis claims that aging is due to shortening of telomeres – DNA molecules caps, that shorten every time a cells undergoes division. Yet the naked mole rat has relatively short telomeres. Also the telomerase, protein that lengthens telomeres, is not really active in naked mole rats’ cells. So telomere maintenance is unlikely to explain the outstanding longevity in these animals.

So what are the reasons for these almost “magical” properties of the naked mole rat? Park and Buffenstein note:

1. Naked mole-rat tissues are better able to recognize abnormal cells, neutralize their tumorigenic properties, and repair their DNA. Should that fail, the cells are ushered into programmed cell death pathways.  This means that errors in the DNA are constantly and effectively repaired or removed, before they give rise to cancer.

2. Many gene families in the mole-rat genome are involved in DNA repair and detoxification processes, and the expression of these genes remains unchanged as the animals age. So, stress resistance genes work perfectly well into the old age.

3. Proteasomes are more abundant and more efficient in degrading the damaged proteins within the cells. Same thing with autophagy – it occurs at a twofold greater rate in naked mole-rat cells than those of the mouse. These two enchanted mechanisms of cellular cleaning resist damage from toxins, heavy metals and DNA-damaging agents. In simple words: better housekeeping means longer life.

This supermodel for research is being studied only in a couple of labs in the world. This is such a shame. I wish more researchers included naked mole rats in their experiments. I wish there were more money for research in naked mole rats, because they may hold the keys to our understanding of the mechanisms responsible for life extension.

4 Comments

Filed under Mechanisms of aging

Bad Cinema

Imagine the following movie plot: A lot of characters. They fall in love, get married, sometimes get divorsed. They dream about something, and they seek something in life. Some of them achieve what they want, others don’t. And after that they all become very sick. They start to loose the ability to see, hear and walk. Some of them start to rot alive, spit blood. The majority is in terrible pain, they suffer and they are lonely. And then they all die.

Here’s another movie. Some people want the future to be the way they want it to be and do a lot to make it happen. Other men and women see their future in a completely different way and conflict with the former. The rest don’t even think about what’s ahead of them. But it’s pain, suffering and death that’s ahead of all of these people, regardless of what they have been planning for themselves.

Oh, and here’s another movie. The characters live for their children. They take care of the kids, parent them, nurture them, love them so much. Then they all die, the kids die too, a lot of them die in the throes.

Millions if movies. Different plots, events, circumstances. Different characters, habits, ideals, goals, meanings. Different people. But the end is the same. Death of everyone.

Not the best cinema, right? I wouldn’t go. Although it’s not a movie. It’s our life. This is the destiny of every person who lived on our planet: pain, suffering and death. There were some who died with no pain, but this doesn’t change their sorrowful fate. There were some who wanted to die. Because of their pain and senile dementia. But it’s not what these people wanted when they were only starting to live.

It’s aging that kills people. Also it’s stupidity and greed that kill people. It exactly the stupidity and greed that prevents people from doing much to survive. The society spends an abysmal amount of effort on life extension. Minimal interest and microscopic funding goes to studying of fundamental mechanisms of aging. Resources are being spent on any galimatias, but not on longevity. Years go by, and people become dung. Because of their own stupidity and imbecility of others.

Almost everyone who comes to somebody’s funeral should keep saying: «We are the sick people, we killed you by our passivity. Moreover, we keep on bringing death further on. The thought to identify the underlying reasons of death and to try to eliminate them doesn’t even steel into our empty minds. It’s actually just money and pleasure what matters to us. Indulging into that we seek our own death.»

When people become better, they will be immortal. Isn’t it about time?

4 Comments

Filed under Life Extension

We Need More Books Like 100 Plus by Sonia Arrison

Wall Street Journal reviewed “100Plus” – a book that argues for longer life, regenerative medicine, aging research and the future of our health. I wish there were more books like this one that promote transhumanism and show that longer lives mean healthier and hapier lives. We need more books that tell the audience how we can achieve life extension. There should be more books and articles that talk about what exactly each person can do to help depending on their occupation, social status and other factors.

1 Comment

Filed under Marketing, Transhumanism