Tag Archives: radical life extension

What Should Be Done to Achieve Radical Life Extension?

Crowd

Theoretically the problem is already solved. It is now quite obvious what kind of research should be done for life extension. For example, testing various combinations of different things that extend lifespan in old mice. Particularly important is longevity gene therapy development.

Delivering 5-7 gene vectors simultaneously carrying longevity-associated genes into an old animal could prove to be quite beneficial, because similar approach already works.

It is also clear that there are several experiments in the area of therapeutic cloning that should be done immediately.

There are about 20 other research directions in the area of radical life extension. I’d like to just also mention implementing aging diagnostics into clinical practice.

There are approximately 50 labs in the states that move into the right direction. They could do much more if they had more money.

Well, it’s all about the money, but not really big money.

Transhumanists from all over the world have been trying to solve the mystery of how to secure funding for reaching physical immortality. The very development of science leads towards it, but this process is too slow, a lot of people may not make it in time. Our goal is to accelerate.

Right now it has become obvious how to find the money for radical life extension. It’s crowdfunding. 200-300 campaigns need to be created on various crowdfunding platforms on the topics of fighting aging and regenerative medicine.

Of course, we may not be able to find the necessary amounts of money right away, but we will be able to delineate the scope of goals, most importantly not using just the general words, but particular scientists, labs and research plans.

Even by only preparing the campaigns we will influence the society by once again providing the proof of the possibility of significant life extension. Unfortunately, molecular biology is not part of an every day’s person background. We will make people more educated, show them how diseases originate, progress, and how they relate to aging. We will also tell the people what can be done.

While working on the crowdfunding campaigns we will mobilize our supporters by giving them a concrete tool and a plan of action. Fighting aging crowdfunding will become a very powerful transhumanist organizational solution.

In the end we will gather the money, implement our projects and win!

If you are interested in bringing this plan to live, let’s collaborate. Every single project requires a manager, analyst, scientist, director, operator, a guy who owns a car and a guy who writes a lot about this on the Internet. There is work for everybody, so let’s do this.

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Can We Live Forever – a Cool Video From the Advanced Apes

Finally – a positive video about radical life extension. It shows three ways of how people can extend their lives using future technologies, and it’s very easy to understand, even if you are not a scientist. I am officially a fan of the people at The Advances Apes, who have created this animation. The more videos like this one circulate among the vast realms of the internet, the more supporters the idea of life extension will have.

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Roadmap to Immortality – Digital Immortality

Roadmap-6-Digital_Immort

We have created the Human Physical Immortality Roadmap to persuade people that radical life extension is possible within our lifetime. The only thing needed is larger scope of scientific research in favor of longevity. Here’s another part of the Roadmap for you.

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Roadmap to Immortality

Roadmapp to immortality

 

We have created the Roadmap to Immortality – a timeline of events that will lead to indefinite human lifespan extension. Some of these evens can happen simultaneously, some separately, some even already happened. I invite everyone to express their opinion, add to the Roadmap, make it more detailed. We need more authors, please, join!

The pdf can be found here – Roadmap_immortality_ENG

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Google Wants to Fund Radical Life Extension Startups

I think you’ve all read the news that Google is to fund radical life extension, cryogenics and nanotechnology. My thoughts about it:

1. I love the sound of it, obviously “We look for entrepreneurs with a healthy disregard for the impossible.” Ah, it’s it beautiful? However, I don’t want to be too happy too prematurely. Even though Google Ventures invests in 23andme and Foundation Medicine, which is not a bad start in the right direction, but we’ll see how it goes and what companies they will choose to support in the future.

2. How do they make sure they won’t invest in the swindlers that crowded the anti-aging field? I wonder how the choosing and verification process is organized and who the experts in radical life extension field are.

3. Why cryogenics, but not cryonics or cryopreservation? Or do they seriously mean freezing metals and other materials? How is that going to save billions of lives?

4. And my major concern – what about basic science? I do realize I writing about a venture fund. However, I believe without investing in the fundamental science behind radical life extension, there will be no radical life extension, but only the frauds who offer snaik oil and claim that it heals all diseases including aging. Investors love simple solutions. There can be no simple solution in radical life extension. We know quite a few examples when investors got severely disappointed when they fell under the spell of simplicity and gave money for a pill to stop aging. Obviously, there can be no single pill, so the investors fell like fools and shut the door of opportunity for good projects. I am very concerned that something similar might happen to Google Ventures. In order to prevent this situation Google Ventures should pay a lot of attention to basic research into the mechanisms of aging and have a well educated and experienced team of experts who can distinguish bad projects from the good ones.

5. Google Ventures has a great potential to improve the attitude to radical life extension and cryonics. By choosing these fields Google sets a terrific example for other companies and agencies, as well as for the public, to pay attention to these topics. This can very quite helpful in creating the positive image of life extension, because everyone knows that Google is no fool and won’t invest in useless things.

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David Gems Argues for Radical Life Extension

I’d like to share a truely great article by David Gems, Assistant Director of the Institute of Healthy Ageing, UCL. In this paper Professor Gems proves that aging is a diseases and encourages researchers and agencies like FDA to view it as a disease. If this happens there will be demand on therapies that decellerate aging and there will be much less anti-aging fraud, because we’ll have strict regulations for anti-aging drugs.  In this article David Gems describes the possible ways to tacle the problem of aging and explains why he thinks that the best way to persue the problem is to try to decelerate aging. In my opinion, one shouldn’t neglect the possibility to arrest aging in general, but I totally agree with Professor Gems that we have to intervene in the fundamental mechanisms of aging, and not just separate diseases, because only this approach will yield in therapies capable of significantly extending our life span and reducing disease risks.

The article represents a wonderful example of how the ethical questions related to aging research and life extension should be answered.

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Poll – How Many People were You Able to Persuade that Scientific Research Aimed at Radical Life Extension is Necessary?

The fight against aging is getting zero support from any global resources and there are no organizational solutions to raise money, but building awareness and funding this important battle is greatly needed. I strongly believe that by spreading the word, we can be successful at attracting a large audience which will help to influence a change in the current situation. The main goal of an immortalist is to advocate the ideas of radical life extension, to build awareness and attract a following. This is the purpose of my blog – to engage in communication with other like-minded individuals and to pursuade people, that radical life extension research is absolutely necessary. Our numbers can grow exponentially. Life extension research needs your help – which brings me to today’s poll:

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Billionaire co-founder of PayPal, Facebook to hold radical life extension summit

Financier and philanthropist Peter Thiel is keen on thinking about the future and he is gathering together some of his 200 fellow entrepreneurs and techies to encourage these philanthropists to donate more money to scientific pursuits that could lead to big breakthroughs in medicine, artificial intelligence and nanotechnology, among other fields.

“We’re living in a world where people are incredibly biased toward the incremental,” said Thiel, explaining that he wants to challenge his peers to pursue more “radical breakthroughs” in their philanthropy by supporting nonprofit exploration of technological innovations that carry at least the promise of major advances for the human condition.

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Scientists Discover New Way to Detect and Fix DNA Damage

Researchers at Vanderbilt University, Pennsylvania State University and the University of Pittsburgh have discovered a new mechanism that detects and repairs a more common form of DNA damage called alkylation.
In a typical day, about one million bases in the DNA of a human cell are damaged. These lesions are caused by a combination of normal chemical activity within the cell and exposure to radiation and toxins coming from environmental sources including cigarette smoke, grilled foods, UV rays and industrial waste. These lesions cause structural damage to the DNA molecule, and can dramatically alter the cell’s way of reading the information encoded in its genes. Luckily, repairing damage and maintaining the integrity of its DNA is one of the cell’s highest priorities. 

As cells age however, the DNA repair process can no longer keep up with ongoing DNA damage. The cell then suffers one of three possible outcomes:
* An irreversible state of dormancy, known as senescence (http://en.wikipedia.org/wiki/Senescence)
* Cell suicide, also known as apoptosis (http://en.wikipedia.org/wiki/Apoptosis) or programmed cell death
* Cancer
When cells become senescent, alterations in their gene regulation cause them to function less efficiently, which inevitably causes disease. The DNA repair ability of a cell is vital to its normal functioning and to the health and longevity of the organism. Many genes that are shown to influence lifespan are associated with DNA damage repair and protection.

“There is a general belief that DNA is ‘rock solid’ – extremely stable,” said Brandt Eichman (http://structbio.vanderbilt.edu/faculty/eichman.php), associate professor of biological sciences at Vanderbilt, who directed the project. “Actually DNA is highly reactive,” he was quoted as saying.
According to the Vanderbilt study, when a DNA base becomes alkylated, it forms a lesion that distorts the shape of the molecule enough to prevent successful replication. Human cells contain a single glycosylase (http://en.wikipedia.org/wiki/DNA_glycosylase), named AAG that repairs alkylated bases. It’s specialized to detect and delete “ethenoadenine” bases, which have been deformed by combining with highly reactive, oxidized lipids in the body.

“It’s hard to figure out how glycosylases recognize different types of alkylation damage from studying AAG since it recognizes so many. So we have been studying bacterial glycosylases to get additional insights into the detection and repair process,” said Eichman.
That is how they discovered the bacterial glycosylase AlkD with its unique detection and deletion scheme. “All the known glycosylases work in basically the same fashion: hey flip out the deformed base and hold it in a special pocket while they excise it. AlkD, by contrast, forces both the deformed base and the base it is paired with to flip to the outside of the double helix.”

“Understanding protein-DNA interactions at the atomic level is important because it provides a clear starting point for designing drugs that enhance or disrupt these interactions in very specific ways,” says Eichman. “So it could lead to improved treatments for a variety of diseases, including cancer.”

So there is a vast body of evidence that correlates DNA damage to death and disease. As indicated by the findings of the Vanderbilt study, increasing the activity of some DNA repair enzymes could cause a decrease in the rate of cell damage which would result in adding many healthy and disease-free years to our aging population.
Read about the DNA Repair study: (http://news.vanderbilt.edu/2010/10/newly-discovered-dna-repair-mechanism/)

Maria Konovalenko 
SCIENCE FOR LIFE EXTENSION FOUNDATION 
http:/mariakonovalenko.wordpress.com/ 
maria.konovalenko@gmail.com

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First step to preserving conciousness – Sebastian Seung: I am my connectome

One of the most intriguing topics in life extension is Neuroscience. In this amazing TED talk Sebastian Seung, Professor of Computational Neuroscience at MIT, tells a story about what may actually be our self – the connectome. The term reffers to the entity of all the connections between neurons in our brain.
Professor Sueng is trying to map the incredibly complex network of neurons by analyzing the images of thin slices of the brain and identifying neural patways.

I’d like to draw your attention to a couple of ideas that are bought up by the researcher.

First of all, he mentioned other people saying the task is too complex and it’s basicly impossible to accomplish. There! This is exactly what is constantly happening to people – they loose hope on solving really complicated problems. No wonder radical life extension is considered an impossible task to implement, but in fact it’s not. It’s just nobody takes into account the acceleration of the scientific progress and the exponential growth of knowledge.

Sebastian Seung says: “Some day, a fleet of miscoscopes will capture every neuron and every synapse in a vast database of images. And some day, artificially intelligent supercomputers will analyze the images without human assistance to summarize them in a connectome. I do not know, but I hope that I will live to see that day.” This is one of the technological challenges, but the problem is finite. There is a finite number of neurons in the brain and a finite number of connections between them. I have no doubt that the problem will be solved in the not-very-distant future.

The other issue is the importance of Professor Seung’s work to radical life extension. Consciousness is believed to be determined by the connectome. If we learn how to preserve our it after the death of the body then we basicly can live forever. Possibly, that can be done by uploading it to a computer. Mapping the neuronal network is the first step to preserving the most precious thing we have – our conciousness.

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