While discussing the longevity gene therapy project we encountered various questions and observations that prompted us to broaden the project and slightly change it. Generally, all the comments can be reduced into 5 main points:
- You need to enlarge the list of therapeutic genes by adding to it this and that.
- You want to use too many genes; therefore you need to make the project simpler by keeping only the most effective genes
- If you apply all the genes at the same time, some of them may cancel out the effects of other genes.
- Will it be safe to use viral vectors to deliver genetic constructs?
- How safe are therapeutic genes for the body?
Some of the observations were of completely opposite nature, so we decided to do 2 versions of the project. One of them is for aging geneticists. In it we almost double the list of the genes extending lifespan. This project will allow testing many poorly studied genes, but promising in terms of aging. Besides, some unexpected results can be obtained, which is always valuable.