Tag Archives: tissue engineering

Days of Molecular Medicine 2011

It seems to be an extremely interesting conference. Just to highlight a couple of talks: Engineering functional liver tissue, Nanofibers and iPS cells for neural regeneration, Exploring stem cell niche interactions at single cell resolution. Take a look at  the whole program. I believe it’s worth visiting, because regenerative medicine is one of the ways of life extension.

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Can We Live Forever – Artificial Organ Regrowth

Regenerative medicine has the potential of being the first solution to the problem of aging. In several years we’ll be able to repace damaged or diseased organs with the new grown ones. The video shows how it can be done. I found the story about the decellularized rat heart scaffold amazing. They actually show what a scaffold looks like and it’s beautiful.

 

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The main result of the year – The first regenerative medicine surgery in Russia

paolo macchiarini, tissue engineering, tissue engineered trachea, regenerative surgery, mikhail batin, russian academy of medical scienses, petrovsky center of surgery, regenerative medicine in russia

For the Science for Life Extension Foundation the main result of the year was the first in Russia unique transplant surgery of a trachea grown from the patient’s own stem cells inside her body. The surgery based on Professor Paolo Macchiarini’s technique was carried out in December in the Petrovsky Research Center of Surgery of the Russian Academy of Medical Sciences in Moscow.

The Foundation spent a full year and a half in order to bring this technology to Russia. We fully financed this project and organized the work between all the collaborators – Russian Academy of Medical Sciences, Petrovsky Research Center of Surgery, Careggi University Hospital in Florence, pharmaceutical companies and manufacturers of biomaterials. The total cost of the project was $330, 000.

Last summer when we learned about the unique surgeries done by Macchiarini, we went to Barcelona where he was the Head of the Thoracic Surgery Department in the Hospital Clinic. We agreed to have him visit Moscow to share his experience with Russian specialists. In February 2010, Paolo gave a master class in the Presidium of the Russian Academy of Medical Sciences. It was at that time when an agreement was reached on introducing his technique in Russia.

In August 2010 Macchiarini came to Russia again to sign the research and clinical collaboration contract with the Petrovsky Research Center of Surgery. Earlier this fall the Foundation organized the training for the employees of the Petrovsky Center  in the Department of Regenerative Surgery and Bio-transplantation at the Careggi University Hospital in Florence, where Professor Macchiarini is the current department head.They studied the process of trachea preparation for transplantation and could watch the surgery live.  Previously, there had been seven other tissue engineered trachea transplants that were performed  in Western Europe and none in the US.

So, on December, 7 such a surgery was carried out in Moscow. The patient was a 26-year old woman. In 2006 she was hit by a car where she sustained very serious injuries, went through a clinical death and stayed comatose for several months. She was unable to breathe on her own and had a tube in her trachea for a long time. As a result the trachea was damaged.  Doctors in Kazakhstan, Israel and China couldn’t help the girl breathe normally. She required constant medical attention and was forced to permanently live in a clinic with frequent surgical interventions..

Then the patient’s mother took her to Moscow, so that she could undergo surgery using Macchiarini’s technique. The technology is as follows: a trachea taken from a dead donor is treated with special compounds until there’s no donor cells left, which elliminates the rejection problem and there’s no need to supress the patient’s immune system. Before the transplantation, the obtained scaffold is treated with the patient’s bone marrow cells and also cells from the mucosa, so that the inner mucosa of the treachea can be formed afterwards. Plus the growth factors are added. There’s also a biodegradable stent placed inside the new trachea. The patient’s body in this case plays a role of the bioreactor, inside of which the new healthy organ is formed during a couple of weeks.

Right now the patient is ready to be discharged – she can talk, breathes much better, is able to walk and undergo a physical load.

This surgery is a great beginning to the implementation of regenerative medicine technologies into human clinical practice. These technologies provide a wide perspective for treating severe illnesses associated with loss of vital organs and tissues and also has let Russian research and clinical institutions become a major player in the international consortium for regenerative medicine.

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Regenerative Medicine Roadmap 1.1

Poster-REG-MED_ENG_04-2011_new

Here is the updated edition of the Roadmap to Regenerative Medicine; the first one can be found here. Cell therapy and tissue engineering are described in more detail, than the rest of the scientific issues. I welcome everybody to take a look and add what’s missing and/or change what’s wrong. I’d also like to note that the organizational issues aren’t described at all, but this is probably the most important part of the roadmap. There should be an implementational plan of how exactly the Roadmap should work included in the organizational part. To do that, we need to address the specialists in the given fields.

But at least for now the question is – what’s missing in the scientific part?

Here you can download the Roadmap Poster-REG-MED_ENG_04-2011_new.

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Regenerative Medicine Roadmap

Okay, this is one of the things that we’re doing in the Science for Life Extension Foundation. It’s the Regenerative Medicine Roadmap Chart, the first draft of the scientific part of the future Roadmap which, I believe, is an essential document for the whole field.

Regenerative Medicine Roadmap Poster, regenerative medicine, regeneration, chart, poster, roadmap, regenerative medicine roadmap, plan, collaboration, tissue engineering, cell therapy

Regenerative medicine is now one of the few rapidly developing fields that have a great potential in significantly improving the quality of life and promoting longevity. It is highly important to create a roadmap in order to enable effective collaboration among the researchers and to multiply the future outcomes of their work.

The purpose of this chart is to create an overview of the field from the scientific point of view and to list the current and future research directions in each area. The goal is to create a draft of the scientific part of the Regenerative Medicine Roadmap, which would set the guidelines for the scientists, provide research plans for the institutions and help attract potential sponsors and investors.

Regenerative Medicine is divided into 5 blocks: Tissue engineering, Cell therapy, Diagnostic platforms, Healing Therapies and Supporting Technologies. The main focus of the chart lies in the Tissue Engineering and Cell Therapy parts. These parts are schematically divided into components, which in turn are described in more detail with specific research directions. Tissue Engineering comprises such areas as methods, cells for use, biomaterials, and database creation. The Cell Therapy part consists of three blocks: cell removal, regenerative capacity restoration and adding cells. Specific research directions listed provide the ground for forming research plans in each particular area. This preliminary work will help create a highly detailed plan of action in regenerative medicine.

We propose a collaboration in creating the Roadmap.
The link to download a pdf of the chart.

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