Roadmap to Immortality – Regenerative Medicine


The Roadmap consists of 7 parts. This is the second one. Any comments and edits are more than welcome. Please, let me know what you think.

Also, if you could suggest a way to publish it somewhere in a nice journal that would be great. Thanks!



Filed under Transhumanism

14 responses to “Roadmap to Immortality – Regenerative Medicine

  1. ED.

    hello, 1-2-3 and perhaps 7 go together (exogenous organ replacements) and is applied with numerous intermediate applications so it should work to some extent if there is sufficient interest.

    4-5-6 (endogenous regrowth) go together, I guess it is very important in that aspect to look at A) why we “regrow less” as we grow older: the old body is like a full house that doesn’t welcome any more cells. It is the first axis of ‘sens’. The immune system is an exemple and perhaps each organ/function has its limits. Scenescents very probably play a role in many systems and getting rid of them could be the main key. B) to have to guide such as mouse lifespan tests. Eg if growth hormone were being invented today and being studied on local, short term aspects, many would claim hurray.

    8: Is there some research/hope in that direction?
    9: it doesn’t necessarily need the rest (except to be tested on lower organisms). but if there a team to work on such aspects.

    Perhaps more important things are lacking. I would put among the very top priorities to have a few consecutive large series of well performed mouse lifespan tests to learn the levers of mammalian longevity within a few years. With the potential to simulatenously ‘clean’/enlight/apply!/guide/demultiply life extension science.

  2. 8 – As a matter of fact in 1937 a brilliant Russian researcher Sergey Bryukhonenko kept a dog’s head alive for several hours. He was the one who invented the very first version of cardiopulmonary bypass. So yes, I’d say there is hope, because no one has even tried to redo his experiments.

    9 – Yes, this part don’t necessarily need the rest. The parts of the Roadmap aren’t supposed to be interdependent. There was this Italian surgeon who wrote an article saying that he knows basically how to do it. I guess money and courage is needed for this kind of an experiment. This could save quite a lot of lives already in the near term future. Especially, when there is a multi organ failure cases and donor bodies from people who are brain dead, for example.

    As for the rest of the comments, I didn’t quite get what your proposals are. Could you, please, explain?

    And I’d like to ask you to formulate the point about testing interventions in mice as a step in this Roadmap. Also, where would you put it?

  3. ED

    My proposal would totally fit in what you called (… I had posted here without seeing the different pages first, sorry) — I will describe in details there, in a few days.
    Though it will probably be relevant for (5) if studying the life extension levers found through mouse lifespan tests reveal that key levers actually serve to help the body regenerate itself (I would guess it because a slow down of regeneration of tissues with age (including bones, muscles, lymphocytes…) seems like a first physical reason for elderlies to be frail).

    Regarding (8), one hour is a brilliant success that should in my opinion lead to (9) rather than (8). I explain:
    – it is brilliant because, typically, cervical dislocation in mice kills the mouse right away, so Bryukhonenko has certainly developped a very complete protocol already for the dog head to be ‘safe’ both during detachment and for some time after (I don’t guess how he does wrt quite some things; will and read the protocol!).
    – it should rather lead to (9) because, typically, extracorporal heart and lung models can not be maintained very long in function as it dries/transforms (Perhaps one day at most; I have worked with such models in rats). So I would think that (8) is much less realistic than other points, and would rather use it for (9).
    How much money would the Italian surgeon need to try (9)? Has he published/posted his ideas of protocol somewhere? Perhaps crowdfunding/individual money could allow him to try.

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  13. Hi Maria, here is a brief history of head transplantations (right up to the present):

    As you know, Italian surgeon, Sergio Canavero of the Turin Advanced Neuromodulation Group (TANG), says he is going to announce plans to conduct the first ever human head (or is it actually a body) transplant during his keynote address at the American Academy of Neurologic and Orthopedic Surgeons this year. He says it could happen within the next two years.

    What do you think?? Many have raised ethical questions about this…just whose body is it anyway?

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